Activation of NMDA receptor ION channels by deep brain stimulation in the PIG visualised with [18F]GE-179 PET

No PET radioligand has yet demonstrated the capacity to map glutamate N-methyl-D-aspartate receptor ion channel (NMDAR-IC) function. [18F]GE-179 binds to the phencyclidine (PCP) site in open NMDAR-ICs and potentially provides a use-dependent PET biomarker of these ion channels.

Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation - April 2, 2020 Category: Neurology Authors: Ali Khalidan Vibholm, Anne Marlene Landau, Aage Kristian Olsen Alstrup, Jan Jacobsen, Kim Vang, Ole Lajord Munk, Martin Jensen Dietz, Dariusz Orlowski, Jens Christian Hedemann S ørensen, David James Brooks Source Type: research