Battelle Earns FDA EUA for Decontaminating Respirator Masks

FDA has granted Emergency Use Authorization (EUA) to Battelle's CCDS Critical Care Decontamination System for processing up to 80,000 respirator masks per system each day. CCDS employs concentrated, vapor-phase hydrogen peroxide (VPHP) for decontamination. The system has been validated to decontaminate masks of SARS-CoV-2, the company reported. The masks are placed on shelves inside a container, and a portable, external VPHP system is hooked up to the outside of container. The system was first envisioned by Battelle as part of a study commissioned by FDA in 2015. That study involved determining the feasibility of N95 respirator mask decontamination in the event of a personal protective equipment (PPE) shortage in a pandemic. The FDA study showed that VPHP decontamination using the same system parameters and critical end points as the current system resulted in 6-log reduction of G. stearothermophilus while not degrading the filter performance of N95 respirators for multiple decontamination cycles, Battelle reported in a news release. "We have proven that VPHP is effective at decontaminating N95 respirator masks up to 20 times at large scale," said Matt Vaughan, president of contract research at Battelle. The masks are exposed to the validated concentration level for 2.5 hours to decontaminate biological contaminates, including SARS-CoV-2, the company reported. Battelle is currently examining whether other supplies such as surgical masks and ventilator components can...
Source: MDDI - Category: Medical Devices Authors: Tags: Sterilization Source Type: news

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This article describes the challenges in CPPs during COVID-19 pandemic and the use of telemedicine as the rescue management vehicle for CPPs in current scenario.
Source: Indian Journal of Anaesthesia - Category: Anesthesiology Authors: Source Type: research
Publication date: Available online 30 May 2020Source: The Journal of Allergy and Clinical Immunology: In PracticeAuthor(s): John C. Carlson
Source: The Journal of Allergy and Clinical Immunology: In Practice - Category: Allergy & Immunology Source Type: research
Authors: Cappannoli L, Scacciavillani R, Iannaccone G, Anastasia G, Di Giusto F, Crea F Abstract From first cases reported on December 31, 2019, in Wuhan, Hubei-China, SARS-CoV2 has spread worldwide and finally the World Health Organization declared the pandemic status. We summarize what makes SARS-CoV2 different from previous highly pathogenic coronaviruses and why it is so contagious, with focus on its clinical presentation and diagnosis, which is mandatory to start the appropriate management and reduce the transmission. As far as infection pathophysiology is still not completely clarified, this review focuses al...
Source: Minerva Cardioangiologica - Category: Cardiology Tags: Minerva Cardioangiol Source Type: research
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Source: Minerva Cardioangiologica - Category: Cardiology Tags: Minerva Cardioangiol Source Type: research
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Source: L Encephale - Category: Psychiatry Tags: Encephale Source Type: research
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Source: Trends in Molecular Medicine - Category: Molecular Biology Authors: Tags: Trends Mol Med Source Type: research
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Source: Clinical Research in Cardiology - Category: Cardiology Source Type: research
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Source: Sensors - Category: Biotechnology Authors: Tags: Letter Source Type: research
The severe acute respiratory syndrome (SARS)-CoV-2 is an emerging viral pathogen responsible for the global coronavirus disease 2019 (COVID)-19 pandemic resulting in significant human morbidity and mortality. Based on preliminary clinical reports, hypoxic respiratory failure complicated by acute respiratory distress syndrome is the leading cause of death. Further, septic shock, late-onset cardiac dysfunction, and multiorgan system failure are also described as contributors to overall mortality. Although extracorporeal membrane oxygenation and other modalities of mechanical cardiopulmonary support are increasingly being uti...
Source: ASAIO Journal - Category: Medical Devices Tags: Management of COVID-19 Patients Source Type: research
The novel coronavirus severe acute respiratory syndrome coronavirus 2 is infecting hundreds of thousands of humans around the globe. The coronavirus disease 2019 (COVID-19) is known to generate mild as well as critical courses. Complications on the intensive care units include acute respiratory distress syndrome, acute cardiac, and kidney injury as well as shock. Here, we present the first case report of a successful treatment of a COVID-19 patient presenting with adult respiratory distress syndrome plus refractory combined cardiogenic and vasoplegic shock, which could be successfully stabilized after implantation of a per...
Source: ASAIO Journal - Category: Medical Devices Tags: Management of COVID-19 Patients Source Type: research
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