BARX2 expression is downregulated by CpG island hypermethylation and is associated with suppressed cell proliferation and invasion of gastric cancer cells.
In conclusion, BARX2 expression is aberrantly reduced in GC, which is associated with increased DNA methylation of its promoter. BARX2 inhibits GC cell proliferation, migration, and tumor formation, suggesting that BARX2 acts as a tumor suppressor in gastric carcinogenesis. PMID: 32236603 [PubMed - as supplied by publisher]
Publication date: Available online 5 June 2020Source: Clinics and Research in Hepatology and GastroenterologyAuthor(s): Zheng Li, Dongqiang Xu, Xudong Tong, Changxing Shan
ConclusionWe suggest that decreased expression of the miRNA-125a-5p associated with the presence of theH. pylori is an important mechanism in gastric diseases and could be a possible marker for early diagnosis of gastric cancer.
Publication date: Available online 5 June 2020Source: Biochimica et Biophysica Acta (BBA) - Molecular Basis of DiseaseAuthor(s): Yueling Zhao, Xiangbo Chen, Jun Jiang, Xuechao Wan, Yuefei Wang, Ping Xu
Conclusion: H. pylori infection is closely associated with the serum level of CD47 in adults, suggesting that H. pylori may promote gastric cancer progression by activating CD47-mediated oncogenic pathways. PMID: 32493095 [PubMed - as supplied by publisher]
CONCLUSIONS: the NACT interval time prior gastrectomy for locally advanced GC is not associated with ypCR or DS and has no impact on overall survival. PMID: 32496120 [PubMed - as supplied by publisher]
Authors: Cheng Y, Di J, Wu J, Shi HT, Zou BC, Zhang Y, Xie DH Abstract OBJECTIVE: Long noncoding RNAs (lncRNAs) display a functional effect on the pathogenesis of several diseases, including various tumors. Herein, we aimed to reveal the role of lncRNA somatostatin receptor 5 antisense RNA 1 (SSTR5-AS1) in gastric cancer (GC). PATIENTS AND METHODS: qRT-PCR was utilized for testing the SSTR5-AS1 expression in 158 paired primary GC tissues and corresponding normal gastric specimens. Receiver operating characteristic (ROC) curves were established to determine the diagnostic values of overexpression of SSTR5-AS1 in...
CONCLUSIONS: In summary, these results indicate that the lncRNA LIFR-AS1 is a promising prognostic indicator in GC patients. PMID: 32495872 [PubMed - in process]
CONCLUSIONS: Circular RNA_LARP4 could suppress cell migration and invasion of PCa by upregulating FOXO3A. PMID: 32495863 [PubMed - in process]
Conclusion: The findings of this study will provide reference and evidence to appraise whether HQNI is an effective on the psychological disorder in patients with GC-PPP Study registration number: INPLASY202040080.
We conducted a study to evaluate the prognostic and diagnostic values of microRNA-10b (miR-10b) in gastric cancer (GC) based on meta-analysis and TCGA database. Relevant studies were searched in English and Chinese database and meta-analysis was conducted on Stata 12.0. The expression value of miR-10b and clinical parameters of GC patients were downloaded from TCGA database, and relevant analyses were conducted on SPSS. High expression of miR-10b was linked with unfavorable overall survival (OS) in GC (HR = 1.572, 95% CI: 1.240–1.992, P