IJERPH, Vol. 17, Pages 2464: Oncological-Therapy Related Oral Mucositis as an Interdisciplinary Problem —Literature Review

IJERPH, Vol. 17, Pages 2464: Oncological-Therapy Related Oral Mucositis as an Interdisciplinary Problem—Literature Review International Journal of Environmental Research and Public Health doi: 10.3390/ijerph17072464 Authors: Kusiak AlicjaJereczek-Fossa Cichońska Alterio Oral mucositis is a toxic side effect of non-surgical cancer treatments: chemotherapy and radiotherapy, which strongly impair quality of life and can not only cause strong pain, but also lead to problems with basic physiological needs as eating and swallowing. Development of oral mucositis is associated with type, dosage, and schedule of radiation or chemotherapy and other factors related to patients. Management of oral mucositis is a valid problem, requiring topical application of anesthetics, coating agents, cryotherapy, low level laser therapy, pharmacological methods as usage of keratinocyte growth factors, supplementation of vitamins, and a proper diet. Another approach to oral mucositis measurement includesphotobiomodulation, which brings analgesic and anti-inflammatory effects.Although oral mucositis is a general health issues, the role of proper dental care is essential. It should include elimination of all potential sources of mucosal injury and microorganisms inhabiting theoral cavity through oral hygiene education,professional management ofdental plaque,and treatment of the caries and periodontium, which are necessary to reduce the risk of inflammation in the oral cavity. Th...
Source: International Journal of Environmental Research and Public Health - Category: Environmental Health Authors: Tags: Review Source Type: research

Related Links:

Conclusion: PR-QOL across several domains declines immediately after SBRT for previously-irradiated rHNC before returning to baseline levels at 1 year. Long-term PR-QOL declines thereafter. Patients with grade ≥3 late toxicities or tumor volume>25 cc report reduced long-term overall PR-QOL, likely representing late disease progression. Specific organ recurrence and grade ≥3 late toxicities predict decrements in specific PR-QOL domains.
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research
ConclusionsThis is the first time comprehensive data on dysphagia and oral complications across all cancer patients have been collected. We have identified that dysphagic symptoms and oral complications —which have implications for quality of life and function—are common in all cancer patients, not just those with head and neck cancer.
Source: Supportive Care in Cancer - Category: Cancer & Oncology Source Type: research
A 24-year-old man with synovial sarcoma was hospitalized for neutropenic fever after chemotherapy, complaining of gingival pain for 1 day. No lymph node involvement was detected during neck palpation. Intraoral exam revealed a purple lesion involving the attached gingiva on the maxilla and mandible, of increased size and with a detachable overlying white plaque. There was rapid evolution to ulcerated lesions, causing an inability to feed. We performed an incisional biopsy and referred the patient for anatomopathologic examination, polymerase chain reaction (PCR), and culture for fungi and bacteria, a prescription of chlorh...
Source: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics - Category: ENT & OMF Authors: Source Type: research
In this study, we aimed at evaluating the frequency of chemoradiotherapy ‑inducedmucositis (CIM, RIM) and its related risk factors in patients with the head ‑and‑neck cancers (HNCs).Materials and Methods: In this cross ‑sectional prospective descriptive study, we evaluated atotal of 54 HNCs patients referred to the Oncology Chemoradiotherapy Department of Razi andAmiralmomenin University Hospitals of Rasht, for site and grade (WHO classification) of CIM/RIM,based on their demographic features and possible risk factors. SPSS software version 18 and statisticaltests (i.e., Fisher ’s exact test) were used, and t...
Source: Dental Research Journal - Category: Dentistry Source Type: research
The Lancet Published:July 20, 2019DOI:https://doi.org/10.1016/S0140-6736(19)31146-8 Oral diseases are among the most prevalent diseases globally and have serious health and economic burdens, greatly reducing quality of life for those affected. The most prevalent and consequential oral diseases globally are dental caries (tooth decay), periodontal disease, tooth loss, and cancers of the lips and oral cavity. In this first of two papers in a Series on oral health, we describe the scope of the global oral disease epidemic, its origins in terms of social and commercial determinants, and its costs in terms of p...
Source: Dental Technology Blog - Category: Dentistry Source Type: news
Conclusions: The improvement in QOL parameters suggests that the regimen of 52.5 Gy in 15 fractions is suitable for palliative intent radiotherapy in late-stage oral cavity cancer for effective palliation for short periods.
Source: Indian Journal of Palliative Care - Category: Palliative Care Authors: Source Type: research
Tongue cancer patients suffer severe, chronic pain driven by oral cancer-induced activation of sensory neurons innervating the oral cavity. However, the impact of sensory neurotransmission on oral carcinogenesis is understudied. Local neurotransmitter release from sensory neurons innervating the cancer has been linked to cancer growth and immune suppression. We hypothesize that oral cancer-induced neurotransmitter release from trigeminal sensory neurons (TGNs) promotes oral cancer proliferation and suppresses the immune response.
Source: The Journal of Pain - Category: Materials Science Authors: Source Type: research
In this study, 24 Sprague-Dawley rats were divided into three groups as control, LLLT, and PT groups. All groups received 5-fluorouracil intraperitoneally and a linear trauma to the mouth pouch with a needle. After the formation of OM in the mouth, the control group had no treatment; the LLLT group was administered LLLT, and the PT group had LLLT after indocyanine green application. Then all groups were sacrificed, and histological analyses and protein level detection of basic fibroblast growth factor (bFGF), transforming growth factor (TGF- β), and platelet-derived growth factor (PDGF-BB) were evaluated in all groups...
Source: Lasers in Medical Science - Category: Laser Surgery Source Type: research
ConclusionsCXPA is an uncommon, high-grade malignant tumor with highly aggressive biologic behavior. Its occurrence in such sites as the soft palate is rare and cause diagnostic difficulties. In this case, a benign pleomorphic adenoma became complicated because of lack of adequate management and the poor choices made by the patient. It underwent high-grade malignant changes and metastasized to various organs of the body, ultimately resulting in the death of the patient.
Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology - Category: ENT & OMF Source Type: research
Conclusion: Systemic treatment with Ivermectin, Albendazole and Clindamycin (Triple Therapy) enhances the removal of maggots, early recovery and relief from distress and associated symptoms.
Source: Indian Journal of Palliative Care - Category: Palliative Care Authors: Source Type: research
More News: Anesthesia | Anesthesiology | Cancer | Cancer & Oncology | Chemotherapy | Cryotherapy | Diets | Education | Environmental Health | International Medicine & Public Health | Laser Therapy | Nutrition | Oral Cancer | Oral Cavity Cancer | Pain | Pain Management | Toxicology | Universities & Medical Training | Vitamins