Breast carcinoma: molecular profiling and updates.

Breast carcinoma: molecular profiling and updates.
Clin Lab Med. 2013 Dec;33(4):891-909
Authors: Bandyopadhyay S, Ali-Fehmi R
Abstract
The most significant contribution of molecular subtyping of breast carcinomas has been the identification of estrogen-positive and estrogen-negative tumor subtypes, which are 2 distinct entities with differing prognoses and requiring different therapy. Molecular and genetic analyses can provide prognostic information; however, a thorough histopathologic evaluation with an evaluation of predictive biomarkers will provide similar information. Knowledge of genetic alterations in these tumors will help identify novel therapeutic targets, which might have an impact on prognosis. Understanding the progression pathways involved in the transition of in situ carcinoma to invasive carcinoma might lead to efficient risk stratification in these patients.
PMID: 24267194 [PubMed - in process]

Source: Clinical Breast Cancer - November 29, 2013 Category: Cancer & Oncology Authors: Bandyopadhyay S, Ali-Fehmi R Tags: Clin Lab Med Source Type: research