Chronic thromboembolic disease following pulmonary embolism: more work ahead

The comment by C. McCabe and colleagues provides thoughtful insights into the late sequalae of pulmonary embolism. The authors' views and suggestions, based on their clinical experience and expertise, may prove helpful in the ongoing process of reliably (and meaningfully) distinguishing chronic thromboembolic pulmonary hypertension (CTEPH) from chronic thromboembolic disease (CTED) without pulmonary hypertension at rest.
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Original Articles: Correspondence Source Type: research

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AbstractObjectivesThe primary objective of the study is to assess the safety of a single intravenous infusion of Mesenchymal Stromal Cells (MSCs) in patients with Acute Respiratory Distress Syndrome (ARDS) due to COVID-19. Secondary objectives are to determine the effects of MSCs on important clinical outcomes, as described below.Trial designREALIST COVID 19 is a randomised, placebo-controlled, triple blinded trial.ParticipantsThe study will be conducted in Intensive Care Units in hospitals across the United Kingdom. Patients with moderate to severe ARDS as defined by the Berlin definition, receiving invasive mechanical ve...
Source: Trials - Category: Research Source Type: clinical trials
This article discusses pMRA techniques and artifacts; performance in commonly encountered pulmonary vascular diseases, specifically pulmonary embolism and pulmonary hypertension; and recent advances in both contrast-enhanced and noncontrast pMRA. PMID: 32471539 [PubMed - as supplied by publisher]
Source: Radiologic Clinics of North America - Category: Radiology Authors: Tags: Radiol Clin North Am Source Type: research
ConclusionsThis case report highlights a presentation of CTEPH in an adolescent with Behcet's disease. A multidisciplinary approach was required for managing this patient's CTEPH, which successfully reversed the patient's pulmonary hypertension.
Source: Journal of Cardiac Surgery - Category: Cardiovascular & Thoracic Surgery Authors: Tags: CASE REPORT Source Type: research
In this study, we explored the possibility of translating lung scintigraphy data consisting of only six planar images (anterior, posterior, left/right posterior oblique, and left/right lateral views) to 3D SPECT volume. We used 119 lung SPECT data acquired using GE Tandem Discovery 670 scanner. Of 119, 104 and 15 images were respectively used for training and testing a deep neural network. The fully convolutional neural network consisting of both two dimensional and 3D convolutional filters was designed. Six 2D images corresponding to the lung scintigraphy scanned from six different views were sampled from the SPECT projec...
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: Data Sciences (Poster Session) Source Type: research
Conclusion: In this study, we proposed a deep learning model to predict V/Q-matched defects based on solely dynamic lung perfusion scan. This technique would help the interpretation when the ventilation scan was interfered by aerosol trapping.
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: Data Sciences (Poster Session) Source Type: research
Conclusions: There were no significant correlations between the pulmonary perfusion indices obtained from 99mTc-MAA SPECT-CT images and the evaluation indices obtained from right-sided heart catheterization.
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: Technologist Poster Session Source Type: research
This article discusses pMRA techniques and artifacts; performance in commonly encountered pulmonary vascular diseases, specifically pulmonary embolism and pulmonary hypertension; and recent advances in both contrast-enhanced and noncontrast pMRA.
Source: Radiologic Clinics of North America - Category: Radiology Authors: Source Type: research
This article discusses the recommended duration of intensive care unit stay after high-intermediate risk or high-risk pulmonary embolism, duration of anticoagulation after venous thromboembolism event, retrieval of inferior vena cava filters, post-hospitalization follow-up and assessment of right ventricular function, and assessment for chronic thromboembolic pulmonary hypertension, chronic thromboembolic disease, and post –pulmonary embolism syndrome.
Source: Critical Care Clinics - Category: Intensive Care Authors: Source Type: research
Authors: Ofori-Acquah SF Abstract Introduction: In sickle cell disease (SCD), hemoglobin S (HbS) red blood cells (RBCs) are characteristically deformed and inflexible. Often breaking down in the circulation, they exhibit increased adhesive properties with the endothelium and activated neutrophils and platelets, increasing the risk of occlusion of the microcirculation. SCD is categorized into two sub-phenotypes: hyperhemolytic, associated with priapism, leg ulcers, pulmonary hypertension, and stroke, and high hemoglobin/viscosity, which may promote vaso-occlusion-associated pain, acute chest syndrome, and osteonecro...
Source: Expert Review of Hematology - Category: Hematology Tags: Expert Rev Hematol Source Type: research
Pulmonary thromboendarterectomy is the standard surgical treatment for chronic thromboembolic pulmonary hypertension (CTEPH) if the surgical risk is reasonable to tolerate a prolonged surgery. The centre and surgeon should also have adequate annual volume of cases to maintain competence. CTEPH may occur in about 4% of patients after an episode of acute pulmonary thromboembolism over a one year period. There are persons with CTEPH who do not have a distinct previous history of acute pulmonary embolism as well. Pulmonary thromboendarterectomy is a technically challenging procedure and hence the importance of operator’...
Source: Cardiophile MD - Category: Cardiology Authors: Tags: Cardiac Surgery chronic thromboembolic pulmonary hypertension CTEPH Source Type: blogs
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