Immune-epidemiological parameters of the novel coronavirus - a perspective.

Immune-epidemiological parameters of the novel coronavirus - a perspective. Expert Rev Clin Immunol. 2020 Apr 01;: Authors: Saghazadeh A, Rezaei N Abstract Introduction: At the end of 2019, Wuhan, a city in China with a population of about 11 million, witnessed the outbreak of unusual pneumonia. As of March 29, 2020, the disease has spread to more 199 countries and territories worldwide. The 2019 novel coronavirus, 2019-nCoV, is known as the probable causative agent of the illness.Areas covered: Here, the epidemiological dynamics of the disease that stand in close relation to distinct immunogenetic characters of the pathogen are discussed, to understand the ability and inability of the immune system in combatting the 2019-nCoV infection.Expert opinion: The elderly population is at increased risk of developing and dying from the 2019-nCoV infection. Comorbidity is present in more than 30% of cases infected with the 2019-nCoV. Except for less than 1% of the total, a chronic condition has been found in all cases that died from 2019-nCoV. Men are more than 1.5 times more likely to die from the 2019-nCoV disease. Evidence links aging to cytokine dysregulation and T-cell repertoire reduction, male population to relatively reduced anti-viral immunity, and 2019-nCoV-related comorbidities to hyper inflammation. The transmission of 2019-nCoV is influenced by the host-related factors that are known to be associated with immune dysregulation. PMID: 32237901 [PubM...
Source: Expert Review of Clinical Immunology - Category: Allergy & Immunology Tags: Expert Rev Clin Immunol Source Type: research

Related Links:

In December 2019, a novel coronavirus called severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) caused an outbreak of coronavirus disease 2019 (COVID-19). Severe complications have been reported to occur in 33% of patients with COVID-19 and include acute respiratory distress syndrome, acute renal failure, acute respiratory injury, septic shock, and severe pneumonia. Currently, there is no specific treatment or approved vaccine against COVID-19 and many clinical trials are currently investigating potential medications to treat COVID-19. The immunosuppressed status of some cancer patients (whether caused by the dis...
Source: American Journal of Clinical Oncology - Category: Cancer & Oncology Tags: Review Article Source Type: research
PNEUMONIA symptoms may be difficult to spot, but they could be linked to the deadly UK coronavirus outbreak. You could be at risk of the lungs bacterial infection if you cough up more phlegm than normal. What colour is your phlegm?
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
Authors: Ambrosino I, Barbagelata E, Ortona E, Ruggieri A, Massiah G, Giannico OV, Politi C, Moretti AM Abstract In December 2019 a novel coronavirus emerged in Wuhan, China causing many cases of severe pneumonia. World Health Organization (WHO) named this disease Coronavirus Disease 2019 (COVID-19). The infection has rapidly spread across China to many other countries, and on March 12, 2020 the WHO declared pandemic outbreak of COVID-19. As of May 16, 2020, COVID-19 has been diagnosed in more than 4,490,000 patients, associated to 305,976 deaths worldwide; in Italy 224,760 COVID-19 cases have been reported with 31...
Source: Monaldi Archives for Chest Disease - Category: Respiratory Medicine Tags: Monaldi Arch Chest Dis Source Type: research
Resolve to Save Lives, an initiative launched by global health organization Vital Strategies, released a playbook that describes four essential actions governments need to take to reopen society quickly and safely in the midst of the COVID-19 pandemic: Test widely—> Isolate infected people—> Find people who have been in contact with infected people—> Ask those people to quarantine for 14 days. Step three—contact tracing—is crucial for controlling spread of the novel coronavirus and for understanding how it spreads. While tech...
Source: MDDI - Category: Medical Devices Authors: Tags: Digital Health Source Type: news
Will Rogers, director of a senior softball tournament scheduled to take place in early June in Columbia, Mo., will be hosting an event that seems inherently dangerous. In the midst of the COVID-19 pandemic, you’d be hard-pressed to find a public health expert who thinks a gathering of 60 teams from various states, with players ranging in age from 40 to 70-plus, is a good idea. The data could not be clearer: older Americans are most at risk of suffering fatal consequences of the disease caused by the novel coronavirus. However, Rogers, who will also suit up to play with the 65-and-over Kansas City Kids at the Missour...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized COVID-19 Source Type: news
Will Rogers, director of a senior softball tournament scheduled to take place in early June in Columbia, Mo., will be hosting an event that seems inherently dangerous. In the midst of the COVID-19 pandemic, you’d be hard-pressed to find a public health expert who thinks a gathering of 60 teams from various states, with players ranging in age from 40 to 70-plus, is a good idea. The data could not be clearer: older Americans are most at risk of suffering fatal consequences of the disease caused by the novel coronavirus. However, Rogers, who will also suit up to play with the 65-and-over Kansas City Kids at the Missour...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized COVID-19 Source Type: news
ConclusionFrom China's experience with novel coronavirus pneumonia, we know that social distancing is the most effective measure at present. We need to win more time to allow limited medical resources to save lives.
Source: Journal of Public Health - Category: Health Management Source Type: research
A commenter asks why people don't count death certificates to determine the actual number of deaths above the norm, since we can't trust the reported Covid-19 deaths. Well, people have done this, and it's pretty disturbing. Researchers who did this in Italy found the actual number of excess deaths to be twice the reported rate. In New York and New Jersey, the excess is at least 50%. This can happen because many deaths are not attributed to Covid-19, whether because they are attributed to influenza or pneumonia in the absence of testing, or because the virus can cause symptoms such as stroke and kidney failure, which is jus...
Source: Stayin' Alive - Category: American Health Source Type: blogs
Conclusions: To the best of our knowledge, this is the first report focusing on COVID-19 infection in a lymphoma patient undergoing intensive immunochemotherapy. For those patients being treated with immunochemotherapy in epidemic areas, a reduced dose intensity of intensive chemotherapy should be considered, and the effect of immunotherapies such as rituximab on COVID-19 infection should be considered. The impacts of anti-cancer treatment on COVID-19 infection need to be explored further.
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research
CONCLUSIONS: The main symptoms of coronavirus disease 2019 pneumonia, including fever and cough, were less common in patients on hemodialysis. Patients on hemodialysis with coronavirus disease 2019 were at higher risk of death. PMID: 32444393 [PubMed - as supplied by publisher]
Source: Clinical Journal of the American Society of Nephrology : CJASN - Category: Urology & Nephrology Authors: Tags: Clin J Am Soc Nephrol Source Type: research
More News: Allergy & Immunology | China Health | Coronavirus | COVID-19 | Epidemiology | Outbreaks | Pneumonia