Immune-epidemiological parameters of the novel coronavirus - a perspective.

Immune-epidemiological parameters of the novel coronavirus - a perspective. Expert Rev Clin Immunol. 2020 Apr 01;: Authors: Saghazadeh A, Rezaei N Abstract Introduction: At the end of 2019, Wuhan, a city in China with a population of about 11 million, witnessed the outbreak of unusual pneumonia. As of March 29, 2020, the disease has spread to more 199 countries and territories worldwide. The 2019 novel coronavirus, 2019-nCoV, is known as the probable causative agent of the illness.Areas covered: Here, the epidemiological dynamics of the disease that stand in close relation to distinct immunogenetic characters of the pathogen are discussed, to understand the ability and inability of the immune system in combatting the 2019-nCoV infection.Expert opinion: The elderly population is at increased risk of developing and dying from the 2019-nCoV infection. Comorbidity is present in more than 30% of cases infected with the 2019-nCoV. Except for less than 1% of the total, a chronic condition has been found in all cases that died from 2019-nCoV. Men are more than 1.5 times more likely to die from the 2019-nCoV disease. Evidence links aging to cytokine dysregulation and T-cell repertoire reduction, male population to relatively reduced anti-viral immunity, and 2019-nCoV-related comorbidities to hyper inflammation. The transmission of 2019-nCoV is influenced by the host-related factors that are known to be associated with immune dysregulation. ...
Source: Expert Review of Clinical Immunology - Category: Allergy & Immunology Tags: Expert Rev Clin Immunol Source Type: research