Results from Expert Delphi Consensus Survey on Treatment of Pulmonary Arterial Hypertension (PAH) with Oral Prostacyclin Pathway Agents (PPAs) Published in CHEST Journal
SOUTH SAN FRANCISCO, CA, April 3, 2020 – Actelion Pharmaceuticals US, Inc., a Janssen Pharmaceutical Company of Johnson &Johnson, today announced that CHEST, the official publication of the American College of Chest Physicians, published results from an expert Delphi consensus survey that help provide additional insights for physicians to advance the care of patients with pulmonary arterial hypertension (PAH).The Prostacyclin International Expert Panel developed the consensus opinions based on common clinical scenarios in which they considered adding oral prostacyclin pathway agents (PPAs), including UPTRAVI® (selexipag), in WHO functional class (FC) II and III PAH patients on endothelin receptor antagonist (ERA) and phosphodiesterase type 5 (PDE-5) inhibitor background therapy. The consensus opinions were formed utilizing the RAND/University of California Los Angeles Appropriateness Method, which incorporates the Delphi method and nominal group technique. Consensus was reached on when they considered adding UPTRAVI for 13 clinical scenarios in PAH patients (WHO FC II and III) with either idiopathic, heritable, and drug- or toxin-induced PAH (IPAH+) or connective tissue disease-associated PAH (PAH-CTD) on ERA and PDE-5 inhibitor background therapy. The panel considered parenteral prostacyclin therapy the treatment of choice in IPAH+ and PAH-CTD patients with high-risk hemodynamics irrespective of other clinical factors.1 The results are not intended to be formal...
Publication date: Available online 29 May 2020Source: Food ChemistryAuthor(s): Halime Uğur, Jale Çatak, Ömer Faruk Mızrak, Nur Çebi, Mustafa Yaman
The objective of this narrative review is to familiarize primary care clinicians with the variety of acute treatment options available in the United States today based on clinical trial findings, meta-analyses, evidence-based guidelines, and professional society consensus statements. PMID: 32459561 [PubMed - as supplied by publisher]
Conclusion: Our findings suggest that suppression of TGF-β-induced signaling by eupatilin might be an effective therapeutic strategy for the treatment of endometrial fibrosis. PMID: 32460455 [PubMed - as supplied by publisher]
Conclusion: The top-quality embryo score at transfer and the degree of post-warming embryo development were associated with clinical pregnancy in vitrified cleavage-stage embryo transfer cycles. In vitrified blastocyst transfer cycles, the top-quality blastocyst score at transfer was the only significant factor affecting clinical pregnancy. PMID: 32456411 [PubMed - as supplied by publisher]
Publication date: Available online 28 May 2020Source: Veterinary MicrobiologyAuthor(s): Yuying Han, Libao Xie, Mengqi Yuan, Yuteng Ma, Huimin Sun, Yuan Sun, Yongfeng Li, Hua-Ji Qiu
CONCLUSION: The women leaders were given a wide range of tasks, despite having a low educational level and receiving training through brief orientations. They also showed limited knowledge but had a relatively high level of activities related to maternal health, while less so on neonatal and child health. PMID: 32456555 [PubMed - in process]
CONCLUSIONS: High-intensity strength training is strongly associated with lower levels of MP in arm-hand, neck-shoulder, and back, whereas no association was found with frequency or lower intensities. PMID: 32464597 [PubMed - as supplied by publisher]
PMID: 32463632 [PubMed - as supplied by publisher]
Publication date: September 2020Source: Microchemical Journal, Volume 157Author(s): Wenjuan Wang, Yeqing Xu, Xiqing Liu, Long Peng, Ting Huang, Yongsheng Yan, Chunxiang Li
This study aimed to confirm whether anosmia and dysgeusia are specific symptoms among those who tested positive for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). METHODS: We conducted an age-matched case-control study in the Eastern Townships region of Quebec between Mar. 10 and Mar. 23, 2020. We included adults (age ≥ 18 yr) who tested positive for SARS-CoV-2 by reverse transcription polymerase chain reaction. Cases were matched (1:1) according to 5-year age groups with control patents selected randomly from among all patients who tested negative for SARS-CoV-2 during the same period. Demographic an...
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