Results from Expert Delphi Consensus Survey on Treatment of Pulmonary Arterial Hypertension (PAH) with Oral Prostacyclin Pathway Agents (PPAs) Published in CHEST Journal

SOUTH SAN FRANCISCO, CA, April 3, 2020 – Actelion Pharmaceuticals US, Inc., a Janssen Pharmaceutical Company of Johnson &Johnson, today announced that CHEST, the official publication of the American College of Chest Physicians, published results from an expert Delphi consensus survey that help provide additional insights for physicians to advance the care of patients with pulmonary arterial hypertension (PAH).The Prostacyclin International Expert Panel developed the consensus opinions based on common clinical scenarios in which they considered adding oral prostacyclin pathway agents (PPAs), including UPTRAVI® (selexipag), in WHO functional class (FC) II and III PAH patients on endothelin receptor antagonist (ERA) and phosphodiesterase type 5 (PDE-5) inhibitor background therapy. The consensus opinions were formed utilizing the RAND/University of California Los Angeles Appropriateness Method, which incorporates the Delphi method and nominal group technique. Consensus was reached on when they considered adding UPTRAVI for 13 clinical scenarios in PAH patients (WHO FC II and III) with either idiopathic, heritable, and drug- or toxin-induced PAH (IPAH+) or connective tissue disease-associated PAH (PAH-CTD) on ERA and PDE-5 inhibitor background therapy. The panel considered parenteral prostacyclin therapy the treatment of choice in IPAH+ and PAH-CTD patients with high-risk hemodynamics irrespective of other clinical factors.1 The results are not intended to be formal...
Source: Johnson and Johnson - Category: Pharmaceuticals Tags: Innovation Source Type: news

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