The Antimelanogenic Effect of Inularin Isolated from Flowers of Inula britannica on B16F10 Melanoma Cells and Zebrafish Embryos.

The Antimelanogenic Effect of Inularin Isolated from Flowers of Inula britannica on B16F10 Melanoma Cells and Zebrafish Embryos.
J Microbiol Biotechnol. 2020 Apr 02;:
Authors: Jang DK, Jung SH, Jeong JH, Yoo HM, Lee IS, Shin HS
Abstract
In the search for novel, natural melanogenesis inhibitors, a new sesquiterpene, inularin, was isolated from the flowers of Inula britannica, and the structure was determined using spectroscopic and chemical methods. The antimelanogenic effects of inularin on B16F10 melanoma cells and zebrafish embryos were evaluated. Inularin dose-dependently reduced melanocyte-stimulating hormone-induced melanin production and L-DOPA oxidation in B16F10 cells. Zebrafish embryos were used to confirm the antimelanogenic activity. Inularin significantly decreased the pigmentation of embryos compared with untreated controls.
PMID: 32238775 [PubMed - as supplied by publisher]

Source: Journal of Microbiology and Biotechnology - April 1, 2020 Category: Biotechnology Authors: Jang DK, Jung SH, Jeong JH, Yoo HM, Lee IS, Shin HS Tags: J Microbiol Biotechnol Source Type: research