Current understanding of metal ions in the pathogenesis of Alzheimer ’s disease

ConclusionThe metal ions imbalance induces A β and tau pathologies by directly or indirectly affecting multiple cellular/subcellular pathways, and the disrupted homeostasis can reversely aggravate the abnormalities of metal ions transportation/deposition. Therefore, adjusting metal balance by supplementing or chelating the metal ions may be p otential in ameliorating AD pathologies, which provides new research directions for AD treatment.
Source: Translational Neurodegeneration - Category: Neurology Source Type: research