Clues to COVID-19 coronavirus's vulnerability emerge from an antibody against SARS

(Scripps Research Institute) An antibody recovered from a survivor of the SARS epidemic in the early 2000s has revealed a potential vulnerability of the new coronavirus at the root of COVID-19, according to a study from scientists at Scripps Research.
Source: EurekAlert! - Infectious and Emerging Diseases - Category: Infectious Diseases Source Type: news

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In this study, we screened nsp15 as the most important viral encoded protein involved in TBK1 and IRF3 reduction. Endoribonuclease (EndoU) activity has been well determined for coronavirus nsp15. Three residues (H226, H241, and K282) of PEDV nsp15 were identified as critical amino acids for PEDV EndoU but not D265, which was not well correlated with published results of other coronaviruses, such as severe acute respiratory syndrome virus (SARS-CoV). Moreover, PEDV nsp15 can directly degrade the RNA levels of TBK1 and IRF3 dependent on its EndoU activity to suppress IFN production and constrain the induction of IFN stimulat...
Source: Viruses - Category: Virology Authors: Tags: Article Source Type: research
The novel coronavirus (SARS-CoV-2) that arose in China in December 2019 resulted in an epidemic that quickly expanded with particular intensity in the United States and European countries, particularly Italy and Spain, devastating the foundations of our nations in one of the most significant public health threats of our time. Sadly, this disease has spread globally, and from March 12 on, the American Society for Reproductive Medicine and European Society of Human Reproduction and Embryology made similarly cautious recommendations on managing patients who were undergoing infertility therapy or desiring pregnancy, but withou...
Source: Fertility and Sterility - Category: Reproduction Medicine Authors: Tags: Inklings Source Type: research
ConclusionThe above-mentioned drugs can be regarded as candidates to treat COVID-19 infections, but further study on the efficiency of these drugs is also necessary.
Source: Journal of Diabetes and Metabolic Disorders - Category: Endocrinology Source Type: research
Conclusions: The outbreak of the epidemic could promote coronavirus research, meanwhile, coronavirus research contributes to overcoming the epidemic. Attention should be drawn to the latest popular research, including “Spike protein,” “Receptor binding domain,” and “Vaccine.” Therefore, more and more efforts will be put into mechanism research and vaccine research and development, which can be helpful to deal with the epidemic.
Source: Medicine - Category: Internal Medicine Tags: Research Article: Systematic Review and Meta-Analysis Source Type: research
Conclusions: Bibliometric analysis of the literature shows the research on coronavirus boomed when a novel coronavirus triggered outbreaks in people. With the end of the epidemic, the research tended to be cooling. Virus identification, pathogenesis, and coronavirus-mediated diseases attracted much attention. We must continue studying the viruses after an outbreak ended.
Source: Medicine - Category: Internal Medicine Tags: Research Article: Systematic Review and Meta-Analysis Source Type: research
THE CORONAVIRUS DISEASE 2019 (COVID-19) outbreak that spread from Wuhan, China, in December 2019 became a global pandemic within about 2 months, causing more than 330,000 deaths worldwide so far (at the time of writing).1 This has forced hospitals in the most affected countries and regions around the world to rearrange their activity, creating new spaces and pathways while reducing nonurgent admissions and health services.2 Although only a minority of patients infected with the new severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) develop symptoms severe enough to require intensive care unit (ICU) admission,3 th...
Source: Journal of Cardiothoracic and Vascular Anesthesia - Category: Anesthesiology Authors: Tags: Editorial Source Type: research
By MICHEL ACCAD Last month marked the 400th anniversary of the birth of John Graunt, commonly regarded as the father of epidemiology.  His major published work, Natural and Political Observations Made upon the Bills of Mortality, called attention to the death statistics published weekly in London beginning in the late 16th century.  Graunt was skeptical of how causes of death were ascribed, especially in times of plagues.  Evidently, 400 years of scientific advances have done little to lessen his doubts!  A few days ago, Fox News reported that Colorado governor Jared Polis ...
Source: The Health Care Blog - Category: Consumer Health News Authors: Tags: COVID-19 Medical Practice Physicians Diagnosis MICHEL ACCAD Source Type: blogs
COVID-19 is caused by the Severe Acute Respiratory Syndrome (SARS) coronavirus (Cov)-2, an enveloped virus with a positive-polarity, single-stranded RNA genome. The initial outbreak of the pandemic began in December 2019, and it is affecting the human health of the global community. In common with previous pandemics (Influenza H1N1 and SARS-CoV) and the epidemics of Middle east respiratory syndrome (MERS)-CoV, CoVs target bronchial and alveolar epithelial cells. Virus protein ligands (e.g., haemagglutinin or trimeric spike glycoprotein for Influenza and CoV, respectively) interact with cellular receptors, such as (dependin...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
AbstractSince the end of 2019, a new coronavirus strain has been reported in the Chinese province of Wuhan, indicated as 2019-nCoV or SARS-CoV-2. In February 2020, the first case of transmission on Italian soil was reported. On March 09, 2020, at the time of protocol design, the Italian Ministry of Health reported 10,149 people who had contracted the virus; of these, 8514 were positive, of which 5038 were hospitalized with symptoms (59.2%) and 877 in intensive care (10.3%), while the remaining 2599 were in home isolation; 631 were deceased (6.2%) and 1004 healed (9.9%). To date there are no studies in the literature that d...
Source: Internal and Emergency Medicine - Category: Emergency Medicine Source Type: research
Yehua Shen, Chien-shan Cheng, Peng Wang, Xu Zhu, Guangyan Lei, Yong Fang, Hailiang Li, Weijun Fan, Hongming Pan, Zhe Tang, Kuansheng Ma, Xiaoguang Li, Zhengyu Lin, Yiping Zhuang, Xin Ye, Bo Zhai, Yue Han, Jinhua Huang, Huixiong Xu, Rongqin Zheng, Rufu Chen, Jie Yu, Dong Xu, Zhongmin Wang, Zhiqiang MengJournal of Cancer Research and Therapeutics 2020 16(2):350-355 The coronavirus disease 2019 (COVID-19) has become a global pandemic since its outbreak in December 2019, which posed a threat to the safety and well-being of people on a global scale. Cancer patients are at high risk of severe acute respiratory syndrome coronavi...
Source: Journal of Cancer Research and Therapeutics - Category: Cancer & Oncology Authors: Source Type: research
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