Coronavirus: Virological findings from patients treated in a Munich hospital

(Charit é - Universit ä tsmedizin Berlin) In early February, research teams from Charit é - Universit ä tsmedizin Berlin, M ü nchen Klinik Schwabing and the Bundeswehr Institute of Microbiology published initial findings describing the efficient transmission of SARS-CoV-2. The researchers' detailed report on the clinical course and treatment of Germany's first group of COVID-19 patients has now been published in Nature*. Criteria may now be developed to determine the earliest point at which COVID-19 patients treated in hospitals with limited bed capacity can be safely discharged.
Source: EurekAlert! - Infectious and Emerging Diseases - Category: Infectious Diseases Source Type: news

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Publication date: Available online 30 May 2020Source: Medical Journal Armed Forces IndiaAuthor(s): Shuvasish Choudhury, Debojyoti Moulick, Purbajyoti Saikia, Muhammed Khairujjaman Mazumder
Source: Medical Journal Armed Forces India - Category: General Medicine Source Type: research
Authors: Cappannoli L, Scacciavillani R, Iannaccone G, Anastasia G, Di Giusto F, Crea F Abstract From first cases reported on December 31, 2019, in Wuhan, Hubei-China, SARS-CoV2 has spread worldwide and finally the World Health Organization declared the pandemic status. We summarize what makes SARS-CoV2 different from previous highly pathogenic coronaviruses and why it is so contagious, with focus on its clinical presentation and diagnosis, which is mandatory to start the appropriate management and reduce the transmission. As far as infection pathophysiology is still not completely clarified, this review focuses al...
Source: Minerva Cardioangiologica - Category: Cardiology Tags: Minerva Cardioangiol Source Type: research
CONCLUSIONS: Further studies are required in order to establish the complicated association between SARS-CoV-2 infection and its effects on the cardiovascular system. Our knowledge regarding diagnostic approaches, therapeutic management and preventive measures is constantly enriched throughout an abundance of ongoing research in the respective fields. PMID: 32472990 [PubMed - as supplied by publisher]
Source: Minerva Cardioangiologica - Category: Cardiology Tags: Minerva Cardioangiol Source Type: research
Abstract The current coronavirus disease 2019 (COVID-19) pandemic is rapidly spreading around the world. The first doctor to report this new disease was an ophthalmologist: this exemplifies the role of ophthalmologists in an infectious disease pandemic. Here we review how severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) affects the eye and discuss implications for ophthalmologists. PMID: 32470381 [PubMed - as supplied by publisher]
Source: Trends in Molecular Medicine - Category: Molecular Biology Authors: Tags: Trends Mol Med Source Type: research
CONCLUSION: Viral RNA of SARS-CoV-2 is detectable in the retina of COVID-19 patients. PMID: 32469258 [PubMed - as supplied by publisher]
Source: Ocular Immunology and Inflammation - Category: Allergy & Immunology Tags: Ocul Immunol Inflamm Source Type: research
In this study, we screened nsp15 as the most important viral encoded protein involved in TBK1 and IRF3 reduction. Endoribonuclease (EndoU) activity has been well determined for coronavirus nsp15. Three residues (H226, H241, and K282) of PEDV nsp15 were identified as critical amino acids for PEDV EndoU but not D265, which was not well correlated with published results of other coronaviruses, such as severe acute respiratory syndrome virus (SARS-CoV). Moreover, PEDV nsp15 can directly degrade the RNA levels of TBK1 and IRF3 dependent on its EndoU activity to suppress IFN production and constrain the induction of IFN stimulat...
Source: Viruses - Category: Virology Authors: Tags: Article Source Type: research
intzios One of the key challenges of the recent COVID-19 pandemic is the ability to accurately estimate the number of infected individuals, particularly asymptomatic and/or early-stage patients. We herewith report the proof-of-concept development of a biosensor able to detect the SARS-CoV-2 S1 spike protein expressed on the surface of the virus. The biosensor is based on membrane-engineered mammalian cells bearing the human chimeric spike S1 antibody. We demonstrate that the attachment of the protein to the membrane-bound antibodies resulted in a selective and considerable change in the cellular bioelectric properties ...
Source: Sensors - Category: Biotechnology Authors: Tags: Letter Source Type: research
Coronaviruses are single-stranded RNA viruses that cause respiratory and intestinal infections in humans. At the beginning of the XXI century, two new coronaviruses with high pathogenicity were described; the severe acute respiratory syndrome coronavirus (SARS-CoV) and the middle east respiratory syndrome coronavirus (MERS-CoV). The coronaviruses (HCoV-NL63, HCoV-229E, HCoV-OC43 and HKU1), were known to cause mild infections in immunocompromised persons. In the Wuhan city, the capital of China's Hubei province in december 2019 a new coronavirus (2019-nCoV) was identified 1,2.
Source: Heart and Lung - Category: Intensive Care Authors: Source Type: research
The severe acute respiratory syndrome (SARS)-CoV-2 is an emerging viral pathogen responsible for the global coronavirus disease 2019 (COVID)-19 pandemic resulting in significant human morbidity and mortality. Based on preliminary clinical reports, hypoxic respiratory failure complicated by acute respiratory distress syndrome is the leading cause of death. Further, septic shock, late-onset cardiac dysfunction, and multiorgan system failure are also described as contributors to overall mortality. Although extracorporeal membrane oxygenation and other modalities of mechanical cardiopulmonary support are increasingly being uti...
Source: ASAIO Journal - Category: Medical Devices Tags: Management of COVID-19 Patients Source Type: research
We present one of the first successful cases of VV-ECMO support to recovery of COVID-19 respiratory failure in North America.
Source: ASAIO Journal - Category: Medical Devices Tags: Management of COVID-19 Patients Source Type: research
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