A complex comprising C15ORF41 and Codanin-1- the products of two genes mutated in congenital dyserythropoietic anemia type I (CDA-I).
We present the characterization of the C15ORF41-Codanin-1 complex in humans in cells and in vitro, and demonstrate that Codanin-1 appears to sequester C15ORF41 in the cytoplasm as previously shown for ASF1. These findings in this study have major implications for the understanding of C15ORF41 and Codanin-1 function and CDA-I.
PMID: 32239177 [PubMed - as supplied by publisher]
Source: The Biochemical Journal - Category: Biochemistry Authors: Shroff M, Knebel A, Toth R, Rouse J Tags: Biochem J Source Type: research