Cancers, Vol. 12, Pages 869: Disruption of Glycogen Utilization Markedly Improves the Efficacy of Carboplatin against Preclinical Models of Clear Cell Ovarian Carcinoma
Cancers, Vol. 12, Pages 869: Disruption of Glycogen Utilization Markedly Improves the Efficacy of Carboplatin against Preclinical Models of Clear Cell Ovarian Carcinoma
Cancers doi: 10.3390/cancers12040869
Authors:
Tashbib Khan
Yaowu He
Thomas Kryza
Brittney S. Harrington
Jennifer H. Gunter
Mitchell A. Sullivan
Tahleesa Cuda
Rebecca Rogers
Claire M. Davies
Amy Broomfield
Madeline Gough
Andy C. Wu
Thomas McGann
S. John Weroha
Paul Haluska
Josephine M. Forbes
Jane E. Armes
Sinead C. Barry
Jermaine I. Coward
Nisha Jagasia
Naven Chetty
Cameron E. Snell
Rohan Lourie
Lewis C. Perrin
John D. Hooper
High stage and recurrent ovarian clear cell carcinoma (OCC) are associated with poor prognosis and resistance to chemotherapy. A distinguishing histological feature of OCC is abundant cytoplasmic stores of glucose, in the form of glycogen, that can be mobilized for cellular metabolism. Here, we report the effect on preclinical models of OCC of disrupting glycogen utilization using the glucose analogue 2-deoxy-D-glucose (2DG). At concentrations significantly lower than previously reported for other cancers, 2DG markedly improves the efficacy in vitro of carboplatin chemotherapy against chemo-sensitive TOV21G and chemo-resistant OVTOKO OCC cell lines, and this is accompanied by the depletion of glycogen. Of note, 2DG doses—of more than 10-fold lower than previously reported for other cancers—significantly im...
Source: Cancers - Category: Cancer & Oncology Authors: Tashbib Khan Yaowu He Thomas Kryza Brittney S. Harrington Jennifer H. Gunter Mitchell A. Sullivan Tahleesa Cuda Rebecca Rogers Claire M. Davies Amy Broomfield Madeline Gough Andy C. Wu Thomas McGann S. John Weroha Paul Haluska Josephine M. Forbes Jane E. Tags: Article Source Type: research
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