Cancers, Vol. 12, Pages 872: Vinorelbine Augments Radiotherapy in Hepatocellular Carcinoma

Cancers, Vol. 12, Pages 872: Vinorelbine Augments Radiotherapy in Hepatocellular Carcinoma Cancers doi: 10.3390/cancers12040872 Authors: Kheng Wei Yeoh Aldo Prawira Muhammad Zafrie Bin Saad Kok Ming Lee Eric Ming Hon Lee Gee Keng Low Mohamed Hakim Bin Mohd Nasir Jun Hao Phua Wendy Wan Li Chow Iris Jiu Hia Lim Yusnita Binte Omar Rebecca Zhi Wen Ho Thi Bich Uyen Le Thanh Chung Vu Khee Chee Soo Hung Huynh There is a need to improve the effectiveness of radiotherapy (RT) in hepatocellular carcinoma (HCC). Therefore, the purpose of this study was to explore the efficacy and toxicity of the anti-microtubule agent Vinorelbine as a radiosensitizer in HCC. The radio sensitivity of 16 HCC patient-derived xenograft (PDX) models was determined by quantifying the survival fraction following irradiation in vitro, and Vinorelbine radio sensitization was determined by clonogenic assay. Ectopic HCC xenografts were treated with a single dose of 8 Gy irradiation and twice-weekly 3 mg/kg Vinorelbine. Tumor growth and changes in the proteins involved in DNA repair, angiogenesis, tumor cell proliferation, and survival were assessed, and the 3/16 (18.75%), 7/16 (43.75%), and 6/16 (37.5%) HCC lines were classified as sensitive, moderately sensitive, and resistant, respectively. The combination of RT and Vinorelbine significantly inhibited tumor growth, DNA repair proteins, angiogenesis, and cell proliferation, and promoted more apoptosis compared with RT or Vino...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Article Source Type: research