Nonclinical safety assessment of repeated administration and biodistribution of a novel rabies self-amplifying mRNA vaccine in rats.

In conclusion, these results showed that the rabies SAM vaccine was well-tolerated by the animals and supported the clinical development program.
PMID: 32240713 [PubMed - as supplied by publisher]

Source: Regulatory Toxicology and Pharmacology : RTP - March 29, 2020 Category: Toxicology Authors: Stokes A, Pion J, Binazon O, Laffont B, Bigras M, Dubois G, Blouin K, Young JK, Ringenberg MA, Ben Abdeljelil N, Haruna J, Rodriguez LA Tags: Regul Toxicol Pharmacol Source Type: research