Sustainable and Selective Alkylation of Deactivated Secondary Alcohols to Ketones by Non-bifunctional Pincer N-heterocyclic Carbene Manganese.

Sustainable and Selective Alkylation of Deactivated Secondary Alcohols to Ketones by Non-bifunctional Pincer N-heterocyclic Carbene Manganese. ChemSusChem. 2020 Mar 31;: Authors: Lan XB, Ye Z, Liu J, Huang M, Shao Y, Cai X, Liu Y, Ke Z Abstract A sustainable and green route to access diverse functionalized ketones via dehydrogenative-dehydrative cross-coupling of primary and secondary alcohols is demonstrated. This borrowing hydrogen approach employing a pincer N -heterocyclic carbene manganese complex displays high activity and selectivity. A variety of primary and secondary alcohols are well tolerant and result in satisfactory isolated yields. Mechanistic studies suggest that this reaction proceeds via a direct outer-sphere mechanism and the dehydrogenation of the secondary alcohol substrates plays a vital role in the rate-limiting step. PMID: 32233008 [PubMed - as supplied by publisher]
Source: ChemSusChem - Category: Chemistry Authors: Tags: ChemSusChem Source Type: research