Functional roles of circular RNAs in Alzheimer's disease.

Functional roles of circular RNAs in Alzheimer's disease. Ageing Res Rev. 2020 Mar 29;:101058 Authors: Huang JL, Su M, Wu DP Abstract Although efforts have been made to develop therapeutic approaches, the clinical management of AD maintains a major challenge. CircRNAs are highly abundant and evolutionarily conserved in neuronal tissues in mammals. Accumulating data suggest that circRNAs regulate biological and pathological processes by sponging miRNAs, binding to RBPs, modulating mRNA stability, and being translated into peptides in various diseases, serving as biomarkers and potential therapeutic targets. Growing evidence demonstrates that circRNAs have been implicated in the pathogenesis of AD. Here, we summarized current studies on circRNAs involved in AD pathology, providing a theoretical basis for the use of circRNAs in AD treatment and diagnosis. PMID: 32234545 [PubMed - as supplied by publisher]
Source: Ageing Research Reviews - Category: Genetics & Stem Cells Authors: Tags: Ageing Res Rev Source Type: research

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Source: Pharmacology Biochemistry and Behavior - Category: Biochemistry Source Type: research
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Source: Medscape Internal Medicine Headlines - Category: Internal Medicine Tags: Psychiatry News Alert Source Type: news
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Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
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Source: Medscape FamilyMedicine Headlines - Category: Primary Care Tags: Psychiatry News Source Type: news
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Source: Talanta - Category: Chemistry Authors: Tags: Talanta Source Type: research
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Source: Fight Aging! - Category: Research Authors: Tags: Daily News Source Type: blogs
The increasing utilization of cerebrospinal fluid (CSF) in early detection of Alzheimer’s disease (AD) is attributed to the change of Amyloid-$beta$ proteins. Since, the brain is suspended in CSF, changes of Amyloid-$beta$ proteins in CSF reflect a pathophysiological variation of the brain due to AD. However, the correlation between Amyloid-$beta$ proteins and the dielectric properties (DPs) of CSF is still an open question. This paper reports the characterized DPs of CSF collected from canines using lumbar punctures. The CSF samples from canines show a strong correlation with respect to human in terms of the loss ta...
Source: IEEE Transactions on Biomedical Circuits and Systems - Category: Biomedical Engineering Source Type: research
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Source: Health News - UPI.com - Category: Consumer Health News Source Type: news
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Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news
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