Exploiting tumor position differences between deep inspiration and expiration in lung stereotactic body radiation therapy planning

Purpose: We demonstrate proof of principle that normal tissue doses can be greatly reduced in lung stereotactic body radiation therapy (SBRT) for mobile tumors, if the delivered dose is split between opposite respiratory states. Methods: Patients that underwent 5 fraction lung SBRT at our institution and had deep inspiration breath hold (DIBH) and free breathing 4D computed tomography scans were included. Volumetric modulated arc therapy plans were generated on both respiratory phases and a third composite plan was generated delivering half the dose using the DIBH plan and the other half using the expiratory phase plan for each fraction.

Source: Medical Dosimetry - April 1, 2020 Category: Radiology Authors: Christina Huang, Kevin Shiue, Greg Bartlett, Namita Agrawal, Mona Arbab, Peter Maxim, Colleen DesRosiers, Todd Mereniuk, Susannah Ellsworth, Ryan Rhome, Jordan Holmes, Mark Langer, Richard Zellars, Tim Lautenschlaeger Source Type: research