Improving outcomes in retinal detachment: the potential role of rho-kinase inhibitors

Purpose of review Retinal detachment initiates a series of events that lead to degenerative changes in retinal synaptic architecture as well as the well-known phenomena of gliosis and photoreceptor apoptosis. Retinal reattachment does not always result in complete visual recovery, even if the fovea is not directly involved in the detachment. Rho-kinase (ROCK) inhibitors may mitigate some of these deleterious changes including disruption of synaptic architecture, photoreceptor apoptosis, and initiation of the epithelial-mesenchymal transition that characterizes proliferative vitreoretinopathy (PVR). This review focuses on the use of ROCK inhibitors to modulate synaptic disjunction. Recent findings ROCK inhibition prevents retinal detachment-induced photoreceptor synaptic terminal retraction (i.e., synaptic disjunction), thereby diminishing the damage of the first synapse in the visual pathway. ROCK inhibition also reduces retinal detachment-induced photoreceptor apoptosis and suppresses PVR progression in preclinical models. Summary Inhibition of ROCK may help to optimize visual recovery after retinal detachment surgery or iatrogenic detachments during cell transplantation or viral subretinal injection and might play a role in reducing the risk of PVR after retinal detachment surgery.
Source: Current Opinion in Ophthalmology - Category: Opthalmology Tags: TRANSLATIONAL RESEARCH: Edited by Jason Hsu and Sunir J. Garg Source Type: research

Related Links:

Condition:   the Efficacy and Effect on Patient Comfort of a Hidden-knot Continuous Suture for Pterygium Excision With Conjunctival Autograft Intervention:   Procedure: suture Sponsor:   Aier School of Ophthalmology, Central South University Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Publication date: September 2020Source: Advances in Medical Sciences, Volume 65, Issue 2Author(s): Agata Duszańska, Jaroslaw Wasilewski, Marek Gierlotka, Michal Zakliczyński
Source: Advances in Medical Sciences - Category: Biomedical Science Source Type: research
Publication date: September 2020Source: Urology Case Reports, Volume 32Author(s): Amadeus Hornemann, Benjamin Hoch, Wolfgang Franz, Marc Sütterlin
Source: Urology Case Reports - Category: Urology & Nephrology Source Type: research
Publication date: Available online 23 May 2020Source: Journal of Pediatric Surgery Case ReportsAuthor(s): Tri Hening Rahayatri, Harsya Dwindaru Gunardi, Rusdah Binti Muhammad Amin, Damayanti Sekarsari, Marini Stephanie, Sastiono Soedibyo, Seisuke Sakamoto, Mureo Kasahara
Source: Journal of Pediatric Surgery Case Reports - Category: Surgery Source Type: research
Condition:   the Efficacy and Effect on Patient Comfort of a Hidden-knot Continuous Suture for Pterygium Excision With Conjunctival Autograft Intervention:   Procedure: suture Sponsor:   Aier School of Ophthalmology, Central South University Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Publication date: Available online 24 May 2020Source: Journal of American Association for Pediatric Ophthalmology and StrabismusAuthor(s): Raymond G. Areaux, Stephen E. Orlin, Gerald W. Zaidman, Kinneri Kothari, Lorri B. Wilson, Jiayan Huang, Gui-shuang Ying, Gil Binenbaum
Source: Journal of American Association for Pediatric Ophthalmology and Strabismus - Category: Opthalmology Source Type: research
Source: Biology of Blood and Marrow Transplantation - Category: Hematology Source Type: research
Source: Biology of Blood and Marrow Transplantation - Category: Hematology Source Type: research
Source: Biology of Blood and Marrow Transplantation - Category: Hematology Source Type: research
Source: Biology of Blood and Marrow Transplantation - Category: Hematology Source Type: research
More News: Opthalmology | Transplants | Vitamin A