Single Coil Implantable Cardioverter Defibrillator Leads in Patients with Hypertrophic Cardiomyopathy

Patients with hypertrophic cardiomyopathy (HC) may require higher energies to terminate ventricular fibrillation (VF); thus, dual coil defibrillation leads are often implanted. However, single coil leads may be preferred in young patients. All patients with HCM implanted with a transvenous ICD from years 2000 to 2014 were included. Of 249 patients, 223 underwent VF testing including 150 with a dual coil lead and 73 a single coil. Patients tested with dual coil compared to single coil had lower successful VF energies (15.7 ± 6.1 joule to 20.2 ± 7.9 joule (p
Source: The American Journal of Cardiology - Category: Cardiology Authors: Source Type: research

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AbstractPurpose of reviewRapid advancements in technology and electronic medical record systems have given rise to massive amounts of cardiac imaging data with the potential to alter medical practices. The rise of machine learning (ML) and radiomics – the concept that images contain invaluable data regarding disease processes beyond what the eyes can see – promises increased precision and accuracy to the current standard of care. Recent advancements in major cardiac imaging modalities, such as echocardiography, cardiac CT and cardiac MRI, h ave uncovered promising diagnostic and prognostic information through t...
Source: Current Treatment Options in Cardiovascular Medicine - Category: Cardiology Source Type: research
Publication date: Available online 9 October 2020Source: The Annals of Thoracic SurgeryAuthor(s): Stijn Vanstraelen, Jeroen Vandenbrande, Alaaddin Yilmaz
Source: The Annals of Thoracic Surgery - Category: Cardiovascular & Thoracic Surgery Source Type: research
Source: Journal of Nuclear Cardiology - Category: Nuclear Medicine Source Type: research
Publication date: Available online 7 October 2020Source: European Journal of RadiologyAuthor(s): Rui Wu, Dong-Aolei An, Ruo-Yang Shi, Bing-hua Chen, Chong-Wen Wu, Meng Jiang, Jian-Rong Xu, Lian-Ming Wu, Jun Pu
Source: European Journal of Radiology - Category: Radiology Source Type: research
Condition:   Cardiomyopathy, Hypertrophic Intervention:   Other: PET Scan Sponsors:   Massachusetts General Hospital;   Brigham and Women's Hospital;   National Heart, Lung, and Blood Institute (NHLBI) Recruiting
Source: - Category: Research Source Type: clinical trials
To determine the potential impact of referral bias on short and long-term outcomes following septal myectomy for hypertrophic cardiomyopathy (HCM).
Source: The Journal of Thoracic and Cardiovascular Surgery - Category: Cardiovascular & Thoracic Surgery Authors: Source Type: research
Hypertrophic cardiomyopathy (HCM) is a very intriguing heritable disease, definied as left ventricular hypertrophy in the absence of a secondary cause. The heterogenity in phenotypic expression makes treatment of patients very challenging. Fortunately, most patients have a benign prognosis, however in a subset of patients the clinical outcome is less favourable as patients present with symptoms of congestive heart failure or sudden cardiac death [1]. Symptoms are often related to left ventricular outflow tract (LVOT) obstruction.
Source: International Journal of Cardiology - Category: Cardiology Authors: Tags: Editorial Source Type: research
Conclusions: Our study found that HCM-associated TNNT2 variants increased cardiac microtissue contraction, while DCM-associated variants cause decreased contraction, both of which paralleled changes in myofilament calcium affinity. Transcriptomic changes, including NPPB levels, directly correlated with sarcomere function and can be utilized to predict TNNT2 variant pathogenicity. PMID: 33025817 [PubMed - as supplied by publisher]
Source: Circulation - Category: Cardiology Authors: Tags: Circulation Source Type: research
In this study, we describe an HCM cohort with a missense variant in CSRP3 (p.Cys150Tyr) with supporting evidence for pathogenicity and a description of the associated phenotype. METHODS: CSRP3 was sequenced in 6,456 index cases with a diagnosis of HCM and in 5,012 probands with other cardiomyopathies. In addition, 3,372 index cases with hereditary cardiovascular disorders other than cardiomyopathies (mainly channelopathies and aortopathies) were used as controls. RESULTS: The p.(Cys150Tyr) variant was identified in 11 unrelated individuals of the 6,456 HCM probands, and it was not identified in patients with othe...
Source: European Journal of Medical Genetics - Category: Genetics & Stem Cells Authors: Tags: Eur J Med Genet Source Type: research
Hypertrophic cardiomyopathy (HCM) is the most common heritable heart disease. Although the genetic cause of HCM has been linked to mutations in genes encoding sarcomeric proteins, the ability to predict clinical outcomes based on specific mutations in HCM patients is limited. Moreover, how mutations in different sarcomeric proteins can result...
Source: Proceedings of the National Academy of Sciences - Category: Science Authors: Tags: Physical Sciences Source Type: research
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