Single Coil Implantable Cardioverter Defibrillator Leads in Patients with Hypertrophic Cardiomyopathy

Patients with hypertrophic cardiomyopathy (HC) may require higher energies to terminate ventricular fibrillation (VF); thus, dual coil defibrillation leads are often implanted. However, single coil leads may be preferred in young patients. All patients with HCM implanted with a transvenous ICD from years 2000 to 2014 were included. Of 249 patients, 223 underwent VF testing including 150 with a dual coil lead and 73 a single coil. Patients tested with dual coil compared to single coil had lower successful VF energies (15.7 ± 6.1 joule to 20.2 ± 7.9 joule (p
Source: The American Journal of Cardiology - Category: Cardiology Authors: Source Type: research

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A mitral L-wave indicates advanced diastolic dysfunction with elevated left ventricular filling pressure. Previous studies have reported that the presence of a mitral L-wave is associated with a poor prognosis in patients with heart failure. However, whether the L-wave can predict adverse events in patients with hypertrophic cardiomyopathy (HC) is still unclear. Therefore, we aimed to investigate the prevalence of a mitral L-wave in patients with HC, and the prognosis of patients with or without an L-wave.
Source: The American Journal of Cardiology - Category: Cardiology Authors: Source Type: research
Condition:   Cardiomyopathy, Hypertrophic Obstructive Interventions:   Drug: CT-20;   Drug: Placebo Sponsor:   Celltrion Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
The phenomenon of high signal intensity on T2-weighted imaging of cardiac magnetic resonance in hypertrophic cardiomyopathy (HCM) has been previously studied. However, the underlying histopathologic mechanism remains unclear. Elevated cardiac troponin can be detected in some HCM patients. A reasonable hypothesis is that high myocardial T2 signal is a potential marker of myocardial injury in HCM. We sought to investigate the association between cardiac troponin and the extent of high T2 signals in HCM patients. Forty-four HCM patients underwent 3.0T cardiac magnetic resonance scanning. On T2-weighted images, the number of ...
Source: Medicine - Category: Internal Medicine Tags: Research Article: Observational Study Source Type: research
Length-dependent activation of calcium-dependent myocardial force generation provides the basis for the Frank-Starling mechanism. To directly compare the effects of mutations associated with hypertrophic cardiomyopathy and dilated cardiomyopathy, the native troponin complex in skinned trabecular fibers of guinea pigs was exchanged with recombinant heterotrimeric, human, cardiac troponin complexes containing different human cardiac troponin T subunits (hcTnT): hypertrophic cardiomyopathy-associated hcTnTR130C, dilated cardiomyopathy-associated hcTnTΔK210 or the wild type hcTnT (hcTnTWT) serving as control. Force-calci...
Source: Frontiers in Physiology - Category: Physiology Source Type: research
Abstract The histone demethylase JMJD family is involved in various physiological and pathological functions. However, the roles of JMJD1A in the cardiovascular system remain unknown. Here, we studied the function of JMJD1A in cardiac hypertrophy. The mRNA and protein levels of JMJD1A were significantly downregulated in the hearts of human patients with hypertrophic cardiomyopathy and the hearts of C57BL/6 mice underwent cardiac hypertrophy induced by transverse aortic constriction (TAC) surgery or isoproterenol (ISO) infusion. In neonatal rat cardiomyocytes (NRCMs), siRNA-mediated JMJD1A knockdown facilitated ISO...
Source: Biomed Res - Category: Research Authors: Tags: Biomed Res Int Source Type: research
AbstractHypertrophic cardiomyopathy (HCM) is a prevalent cardiomyopathy in children, with variable etiologies, phenotypes, and associated syndromic genetic disorders (GD). The spectrum of evaluation in this heterogeneous population has not been well described. We aimed to describe mortality and medical management in the pediatric HCM population, and compare HCM pediatric patients with GD to those without GD. Children (
Source: Pediatric Cardiology - Category: Cardiology Source Type: research
Source: Journal of Echocardiography - Category: Cardiology Source Type: research
Condition:   Hypertrophic Cardiomyopathy Intervention:   Device: Cardioverter-defibrillator Sponsor:   Poznan University of Medical Sciences Completed
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
by Sathiya N. Manivannan, Sihem Darouich, Aida Masmoudi, David Gordon, Gloria Zender, Zhe Han, Sara Fitzgerald-Butt, Peter White, Kim L. McBride, Maher Kharrat, Vidu Garg Hypertrophic cardiomyopathy (HCM) is characterized by the thickening of the ventricular muscle without dilation and is often associated with dominant pathogenic variants in cardiac sarcomeric protein genes. Here, we report a family with two infants diagnosed with infantile-onset HCM and mitral val ve dysplasia that led to death before one year of age. Using exome sequencing, we discovered that one of the affected children had a homozygous frameshift vari...
Source: PLoS Genetics - Category: Genetics & Stem Cells Authors: Source Type: research
Condition:   Hypertrophic Cardiomyopathy Intervention:   Device: Cardioverter-defibrillator Sponsor:   Poznan University of Medical Sciences Completed
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
More News: Cardiology | Cardiomyopathy | Heart | Hypertrophic Cardiomyopathy