Predominant DICER1 pathogenic Variants in Pediatric Follicular Thyroid Carcinomas.

Conclusions Pediatric FTCs have distinct genomic alterations and pathogenesis compared to adults, particularly those characterized by DICER1 variants. The DICER1 variant should be considered in pediatric FTCs, especially in cases < 10 years of age. In all DICER1 variant-positive FTCs and FAs, recurrent hotspot variants were found at metal binding sites within the RNase IIIb domain, suggesting they impact tumorigenesis. PMID: 32228164 [PubMed - as supplied by publisher]
Source: Thyroid : official journal of the American Thyroid Association - Category: Endocrinology Tags: Thyroid Source Type: research