Activation of Muscarinic Receptors Protects against Retinal Neurons Damage and Optic Nerve Degeneration In Vitro and In Vivo Models.

CONCLUSIONS: Taken together, this highlights pilocarpine through the activation of muscarinic receptors appear to afford significant protection against retinal neurons damage and optic nerve degeneration at clinically relevant concentrations. These data also further support muscarinic receptors as potential therapeutic neuroprotective targets in glaucoma. PMID: 24279639 [PubMed - as supplied by publisher]

http://www.ncbi.nlm.nih.gov/pubmed/24279639?dopt=Abstract

Source: CNS Neuroscience and Therapeutics - November 27, 2013 Category: Neuroscience Authors: Tan PP, Yuan HH, Zhu X, Cui YY, Li H, Feng XM, Qiu Y, Chen HZ, Zhou W Tags: CNS Neurosci Ther Source Type: research