Heat Shock Protein 70 Reduces α-Synuclein-Induced Predegenerative Neuronal Dystrophy in the α-Synuclein Viral Gene Transfer Rat Model of Parkinson's Disease.

CONCLUSIONS: These data confirm that overexpression of Hsp70 holds significant potential as a disease-modulating therapeutic approach for Parkinson's disease, with protective effects against early-onset α-synuclein-induced pathology demonstrated in the AAV-α-synuclein model. PMID: 24279716 [PubMed - as supplied by publisher]
Source: CNS Neuroscience and Therapeutics - Category: Neuroscience Authors: Tags: CNS Neurosci Ther Source Type: research