How do we decide to de-isolate COVID-19 patients?

Publication date: Available online 1 April 2020Source: Journal of Microbiology, Immunology and InfectionAuthor(s): Chia-Hung Liao, Shih-Chang Hung, Yuan-Ti Lee, Hung-Chang Hung, Po-Ren Hsueh
Source: Journal of Microbiology, Immunology and Infection - Category: Microbiology Source Type: research

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As of April 21, 2020, more than 2.5 million cases of coronavirus disease 2019 (COVID-19), caused by the SARS-CoV-2 virus, have been reported in 210 countries and territories, with the death toll at 171,810. Both chloroquine and hydroxychloroquine have gained considerable media attention as possible therapies, resulting in a significant surge in demand. In overdose, both medications can cause severe, potentially life-threatening effects. Here, we present a brief overview of the pharmacology of chloroquine and hydroxychloroquine, manifestations of toxicity, and treatment considerations.
Source: Western Journal of Emergency Medicine - Category: Emergency Medicine Source Type: research
The coronavirus disease 2019 (COVID-19), seems to have a cardiovascular tropism characterized by high incidence of myocardial infarction especially for patients with severe infections recovered in intensive care units. In their letter, the Authors state that oxidative stress could play a pivotal role to determine cardiovascular complications in COVID-19. We agree about this issue. In particular, NADPH oxidase-2 (NOX-2), that it is considered one of the most important sources of superoxide anion in human [1], plays a role in systemic inflammation and pathogenesis of several RNA virus as the influenza virus [2].
Source: International Journal of Cardiology - Category: Cardiology Authors: Tags: Letter to the editor Source Type: research
Additionally, side effects were more common among participants in the HCQ group than the placebo group. One expert says the results raise the question of whether some ongoing trials should stop.Medscape Medical News
Source: Medscape Allergy Headlines - Category: Allergy & Immunology Tags: Infectious Diseases News Source Type: news
Authors: Kerboua KE Abstract COVID-19 exhibits a non-yet elucidated heterogeneity dominated by mild form of the illness. Nevertheless, mortality is frequent among patients with a delayed innate immune response that suddenly exacerbates during the second week after admission leading to a lethal over inflammation. Therefore, this rapid and unpredictable deterioration requires timely prediction of COVID-19 refractoriness and critical illness. The two biomarkers readily available in routine laboratories, blood lymphocytes and neutrophil counts, are expected to provide an accurate clinical tool to incline reasonable med...
Source: Immunological Investigations - Category: Allergy & Immunology Tags: Immunol Invest Source Type: research
Publication date: Available online 2 June 2020Source: Biosensors and BioelectronicsAuthor(s): Feiyun Cui, H. Susan Zhou
Source: Biosensors and Bioelectronics - Category: Biotechnology Source Type: research
Authors: Arrese M PMID: 32482463 [PubMed - as supplied by publisher]
Source: Annals of Hepatology - Category: Gastroenterology Tags: Ann Hepatol Source Type: research
This article is licensed under aCreative Commons Attribution 3.0 Unported Licence.Michael P. McRae, Glennon W. Simmons, Nicolaos J. Christodoulides, Zhibing Lu, Stella K. Kang, David Fenyo, Timothy Alcorn, Isaac P. Dapkins, Iman Sharif, Deniz Vurmaz, Sayli S. Modak, Kritika Srinivasan, Shruti Warhadpande, Ravi Shrivastav, John T. McDevitt The COVID-19 Severity Score combines multiplex biomarker measurements and risk factors in a statistical learning algorithm to predict mortality. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Lab Chip latest articles - Category: Chemistry Authors: Source Type: research
Discussion volume is unique in the hundred plus year history of the Faraday Discussion series. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Faraday Discuss. latest articles - Category: Chemistry Authors: Source Type: research
One of America’s most immediate needs is to assess the spread of COVID-19 by quickly and widely testing for infection. That’s where Aperiomics comes in to play. This small business in Ashburn, VA, with early-stage research and development funding from the National Science Foundation’s Small ...This is an NSF Multimedia Gallery item.
Source: NSF Multimedia Gallery - Category: Science Source Type: video
Abstract Coronavirus disease 2019 was first reported from Wuhan district of China and has spread to 210 countries across the world claiming over 97,602 human lives as on 10 April 2020 by 21:06 pm. Currently, there is no specific treatment for this virus and the treatment is mainly relied on controlling symptoms. Here we discuss our current understanding of SARS-CoV-2 with respect to its receptor recognition and how this knowledge could be useful in treatment using clinically known inhibitory drugs. We have also discussed the diagnosis, treatment and preventive measures that are currently being employed for control...
Source: Journal of Genetics - Category: Genetics & Stem Cells Authors: Tags: J Genet Source Type: research
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