Diagnostic Impact of CSF Biomarkers in a Local Hospital Memory Clinic Revisited.

CONCLUSIONS: Our study results corroborate earlier findings that the CSF tool is of added value to the diagnostic workup in daily clinical practice outside tertiary referral centers. CSF levels can best be used in patients under 66 years of age. Given the limited use of this tool in settings outside research facilities, we recommend that the usefulness of CSF biomarkers is studied in a multicenter study. When in the future CSF levels can be reliably measured in plasma, this may become even more relevant. PMID: 32224618 [PubMed - as supplied by publisher]
Source: Dementia and Geriatric Cognitive Disorders - Category: Psychiatry Tags: Dement Geriatr Cogn Disord Source Type: research

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Conditions:   Alzheimer Disease;   Dementia Interventions:   Device: tDCS device model Soterix mini-CT (Soterix Medical Inc., New York, NY) programed to deliver active tDCS.;   Device: tDCS device model Soterix mini-CT (Soterix Medical Inc., New York, NY) programed to deliver sham tDCS. Sponsors:   Albert Einstein College of Medicine;   MJHS Institute for Innovation in Palliative Care Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
An experimental tau inhibitor in development for Alzheimer's also has significant pharmacologic activity in bvFTD, a rare, rapidly progressive type of dementia that affects those younger than 65.Medscape Medical News
Source: Medscape Today Headlines - Category: Consumer Health News Tags: Psychiatry News Source Type: news
Alzheimer's disease (AD) has an estimated prevalence of 50 million persons worldwide1 and an incidence of 10 million cases per year1-3, making it the most common form of dementia. While neuropsychiatric symptoms (NPS) are common in AD, apathy is particularly frequent, affecting up to 70% of patients4. Apathy has been broadly defined as a loss of interest in daily activities and diminished goal directed behavior in the absence of depression and other mood changes5 –7 . This NPS is associated with greater functional impairment, greater caregiver burden, increased risk of institutionalization, poorer quality of life, an...
Source: The American Journal of Geriatric Psychiatry - Category: Geriatrics Authors: Tags: Regular Research Article Source Type: research
Two copies of the APOE4 variant, which confers a higher risk of dementia, doubles the risk of severe symptoms as a result of infection with SARS-CoV-2, according to a study.
Source: The Scientist - Category: Science Tags: News & Opinion Source Type: news
The increasing ageing global population is causing an upsurge in ailments related to old age, primarily dementia and Alzheimer's disease, frailty, Parkinson's, and cardiovascular disease, but also a general need for general eldercare as well as active and ...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Age: Elder Adults Source Type: news
AbstractAlzheimer ’s disease (AD) is the most prevalent dementia in the world. Its cause(s) are presently largely unknown. The most common explanation for AD, now, is the amyloid cascade hypothesis, which states that the cause of AD is senile plaque formation by the amyloid β peptide, and the formation of neurofib rillary tangles by hyperphosphorylated tau. A second, burgeoning theory by which to explain AD is based on the infection hypothesis. Much experimental and epidemiological data support the involvement of infections in the development of dementia. According to this mechanism, the infection either dire ct...
Source: CNS Drugs - Category: Neurology Source Type: research
AbstractMultiple studies have investigated the disruptions in structural and functional connectivity in aging, dementia and Alzheimer ’s disease (AD). The study of metabolic connectivity between brain regions using fluorodeoxyglucose positron emission tomography (FDG-PET) however, is a new focus of interest. Several methodological approaches, including seed-based correlation, independent and principal component analysis, and gra ph-theoretical approaches have been employed to study the metabolic disconnectivity in AD. We conducted a systematic search of the literature using the keywords metabolic connectivity and Alz...
Source: Clinical and Translational Imaging - Category: Radiology Source Type: research
DEMENTIA currently has no cure, but scientists have been looking into ways different types of dementia can be prevented. In a new study, three foods have been shown to have protective benefits against Alzheimer's disease.
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
HDAC1 is involved in a form of DNA repair, but levels decline with age, as well as in Alzheimer's disease. This leads to a greater accumulation of unrepaired oxidative DNA damage in neurons. Researchers here note that increased activation of HDAC1 appears to improve cognitive function via a reduction in this oxidative DNA damage. An HDAC1 activator drug has been tested as a treatment for dementia, but caused serious side-effects. Better compounds or other approaches may be able to obtain similar benefits without the harms. There are several members of the HDAC family of enzymes, and their primary function is to m...
Source: Fight Aging! - Category: Research Authors: Tags: Daily News Source Type: blogs
Conclusions: The presence and extent of methodical issues affecting TMS and tDCS research involving patients with AD and MCI were examined for the first time. The risk of bias frequently affected the domains of the randomization process and selection of the reported data while missing outcome was rare. Unclear reporting was present involving randomization, allocation concealment, and blinding. Methodological awareness can potentially reduce the high variability of the estimates regarding the effectiveness of TMS and tDCS. Studies with low risk of bias delineate a range within TMS parameters seem to be effective but questio...
Source: Frontiers in Human Neuroscience - Category: Neuroscience Source Type: research
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