Molecules, Vol. 25, Pages 1628: Glutamine Analogues Impair Cell Proliferation, the Intracellular Cycle and Metacyclogenesis in Trypanosoma cruzi
In this study, we analysed the effect of glutamine analogues on the parasite life cycle. Here, we show that glutamine analogues impair cell proliferation, the developmental cycle during the infection of mammalian host cells and metacyclogenesis. Taken together, these results show that glutamine is an important metabolite for T. cruzi survival and suggest that glutamine analogues can be used as scaffolds for the development of new trypanocidal drugs. These data also reinforce the supposition that glutamine metabolism is an unexplored possible therapeutic target.
Source: Molecules - Category: Chemistry Authors: Rodolpho Ornitz Oliveira Souza Marcell Crispim Ariel Mariano Silber Fl ávia Silva Damasceno Tags: Article Source Type: research
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