Photodynamic Therapy for Gastrointestinal Cancer

The clinical application of photodynamic therapy (PDT) for gastrointestinal (GI) neoplastic lesions has been developed with appreciation for the great efforts and kind support of Dr. Tom Dougherty and his followers ’ contributions.There are several published studies on clinical PDT in the field of GI oncology including esophageal cancer, Barret’s esophagus, gastric cancer, biliary cancer and pancreatic cancer. In this review, we overview the history, present status and future perspective of PDT for GI canc er in clinical. AbstractThe clinical application of photodynamic therapy (PDT) for gastrointestinal (GI) neoplastic lesions has been developed with appreciation for the great efforts and kind support of Dr. Tom Dougherty and his followers ’ contributions. There are several published studies on clinical PDT in the field of GI oncology. Esophageal cancer was one of the first clinical indications for PDT that was approved as an endoscopic procedure in both the United States and Japan. PDT was initially used as a palliative local treat ment for patients with obstructive esophageal cancer. PDT is also indicated for eradicative therapy for dysplastic Barret’s esophagus, which is the precursor state of esophageal adenocarcinoma, with the support of level one evidence. In Japan, PDT was approved as a curative treatment for superfici al esophageal carcinoma lesions, which are difficult to treat with endoscopic resection. Further, PDT using second‐generation photosensitizer...
Source: Photochemistry and Photobiology - Category: Science Authors: Tags: Special Issue Invited Review Source Type: research