Genetic Architecture of Gene Expression in European and African Americans: An eQTL Mapping Study in GENOA

Most existing expression quantitative trait locus (eQTL) mapping studies have been focused on individuals of European ancestry and are underrepresented in other populations including populations with African ancestry. Lack of large-scale well-powered eQTL mapping studies in populations with African ancestry can both impede the dissemination of eQTL mapping results that would otherwise benefit individuals with African ancestry and hinder the comparable analysis for understanding how gene regulation is shaped through evolution.

Source: The American Journal of Human Genetics - March 25, 2020 Category: Genetics & Stem Cells Authors: Lulu Shang, Jennifer A. Smith, Wei Zhao, Minjung Kho, Stephen T. Turner, Thomas H. Mosley, Sharon L.R. Kardia, Xiang Zhou Tags: Article Source Type: research