Trichodermaloids A-C, Cadinane Sesquiterpenes from a Marine Sponge Symbiotic Trichoderma sp. SM16 Fungus.

Trichodermaloids A-C, Cadinane Sesquiterpenes from a Marine Sponge Symbiotic Trichoderma sp. SM16 Fungus.
Chem Biodivers. 2020 Mar 30;:
Authors: Cui J, Shang RY, Sun M, Li YX, Liu HY, Lin HW, Jiao WH
Abstract
Three new cadinane sesquiterpenes, trichodermaloids A (1), B (2), and C (5) were isolated from a symbiotic fungus Trichoderma sp. SM16 derived from the marine sponge Dysidea sp., together with three known ones, aspergilloid G (3), rhinomilisin E (4), and rhinomilisin G (6). The complete structures of three new compounds were determined by HR-MS and NMR spectroscopic analyses coupled with ECD calculations. The absolute configurations of two known compounds (4 and 6) were determined for the first time. The six isolates were inactive as antibacterial agents. However, trichodermaloids A and B have shown cytotoxicity on human NCIH-460 lung, NCIC-H929 myeloma, and SW620 colorectal cancer cell lines with IC50 values at the range of 6.8-12.7 μm.
PMID: 32227588 [PubMed - as supplied by publisher]

Source: Chemistry and Biodiversity - March 29, 2020 Category: Biochemistry Authors: Cui J, Shang RY, Sun M, Li YX, Liu HY, Lin HW, Jiao WH Tags: Chem Biodivers Source Type: research