Impact of a Multifaceted Antimicrobial Stewardship Intervention in a Primary Health Care Area: A Quasi-Experimental Study

The aim of the study was to evaluate the impact of a multifaceted antimicrobial stewardship intervention on antibiotic consumption in a primary health care (PHC) area in Spain. Quasi-experimental study conducted in a PHC area with nine PHC centers, a 400-bed acute care teaching hospital, and 18 nursing homes serving a population of 260,561. The intervention was based on the 2016 CDC Core Elements of Outpatient Antibiotic Stewardship publication and targeted 130 PHC physicians, 41 PHC pediatricians, 19 emergency physicians, and 18 nursing home physicians. The components were commitment, actions for improving antibiotic prescribing, tracking and feedback, and education and experience. The primary outcome was overall antibiotic consumption. Secondary outcomes were consumption of antibiotics to treat pharyngotonsillitis, acute otitis media, acute sinusitis, acute bronchitis, and urinary tract infection (UTI), percentage of patients treated with specific antibiotics, and dispensing costs. Consumption was measured in defined daily doses per 1,000 inhabitants per day (DID) and compared pre- and postintervention (2016 vs. 2018). Overall antibiotic consumption decreased from 16.01 to 13.31 DID (−16.85%). Consumption of amoxicillin/clavulanic acid and quinolones decreased from 6.04 to 4.72 DID (−21.88%) and 1.64 to 1.23 DID (−25.06%), respectively. The percentage of patients treated with antibiotics decreased from 26.99 to 22.41%. The intervention resulted in cost sav...
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research

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Publication date: Available online 30 May 2020Source: Comparative Immunology, Microbiology and Infectious DiseasesAuthor(s): Gustavo Ortiz-Díez, Raúl López Gallifa, Ana María Sánchez-Díaz, María-Carmen Turrientes, María-Rosario Baquero Artigao, Ruth Luque Mengíbar, Alba Maroto Tello, Cristina Fernández Pérez, Tania Ayllón Santiago
Source: Comparative Immunology, Microbiology and Infectious Diseases - Category: Infectious Diseases Source Type: research
Publication date: Available online 30 May 2020Source: Comparative Immunology, Microbiology and Infectious DiseasesAuthor(s): Ahmad Erfanmanesh, Arash Ghalyanchilangeroudi, Donya Nikaein, Hossein Hosseini, Tahereh Mohajerfar
Source: Comparative Immunology, Microbiology and Infectious Diseases - Category: Infectious Diseases Source Type: research
In this study, 109 type 1 Gaucher disease patients were analyzed with the xTAG®CYP2D6 kit to identify the CYP2D6 gene alleles. RESULTS: We observed that eighty-seven patients could be classified as extensive, 14 as intermediate, 6 as poor and 2 as ultra-rapid metabolizers. The allelic duplication frequency is 5.5% and deletion is 4.5%. The most common allele is wild-type and the second is the null *4 allele. Intermediate phenotype frequency is higher than expected (p
Source: Medicina Clinica - Category: General Medicine Tags: Med Clin (Barc) Source Type: research
Publication date: Available online 30 May 2020Source: Prostaglandins, Leukotrienes and Essential Fatty AcidsAuthor(s): R. Barreiro, P. Regal, O. López-Racamonde, A. Cepeda, C. Fente
Source: Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA) - Category: Lipidology Source Type: research
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Source: Guardian Unlimited Science - Category: Science Authors: Tags: Coronavirus outbreak World news US news UK news Australia news Science Infectious diseases Brazil Russia China Americas Asia Pacific Medical research Europe Microbiology Africa Middle East and North Africa Source Type: news
Publication date: August 2020Source: Journal of Food Composition and Analysis, Volume 91Author(s): Ana Haro, Antonio Trescastro, Luis Lara, Ignacio Fernández-Fígares, Rosa Nieto, Isabel Seiquer
Source: Journal of Food Composition and Analysis - Category: Food Science Source Type: research
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Source: Molecules - Category: Chemistry Authors: Tags: Article Source Type: research
ewski Antibiotics were initially natural substances. However, nowadays, they also include synthetic drugs, which show their activity against bacteria, killing or inhibiting their growth and division. Thanks to these properties, many antibiotics have quickly found practical application in the fight against infectious diseases such as tuberculosis, syphilis, gastrointestinal infections, pneumonia, bronchitis, meningitis and septicemia. Antibiotic resistance is currently a detrimental problem; therefore, in addition to the improvement of antibiotic therapy, attention should also be paid to active metabolites in the body, ...
Source: Molecules - Category: Chemistry Authors: Tags: Review Source Type: research
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Source: Journal of Thrombosis and Thrombolysis - Category: Hematology Source Type: research
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Source: Chemosphere - Category: Chemistry Authors: Tags: Chemosphere Source Type: research
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