Towards harmonization of voriconazole CLSI and EUCAST breakpoints for Candida albicans using a validated in vitro pharmacokinetic/pharmacodynamic model.
Conclusion. A PK/PD breakpoint of C. albicans voriconazole at the ECOFF/ECV of 0.03 mg/L was determined for both EUCAST/CLSI methods, indicating the need for breakpoint harmonization for the reference methodologies.
PMID: 32229492 [PubMed - as supplied by publisher]
Source: Antimicrobial Agents and Chemotherapy - Category: Microbiology Authors: Beredaki MI, Georgiou PC, Siopi M, Kanioura L, Andes D, Arendrup MC, Mouton JW, Meletiadis J Tags: Antimicrob Agents Chemother Source Type: research