Cytotoxic and anti-inflammatory effects of lignans and diterpenes from Cupressus macrocarpa.

Cytotoxic and anti-inflammatory effects of lignans and diterpenes from Cupressus macrocarpa.
Bioorg Med Chem Lett. 2020 Mar 20;:127127
Authors: Al-Sayed E, Ke TY, Hwang TL, Chen SR, Korinek M, Chen SL, Cheng YB
Abstract
Cupressus macrocarpa is a windbreak tree and is reported to have various cytotoxic effects. A natural product study on the leaves of C. macrocarpa has yielded ten secondary metabolites, including three new diterpenoids (1-3), four known diterpenoids (4-7), and three known lignans (8-10). The structures of all isolated compounds were elucidated via the interpretation of spectroscopic methods, especially 2D NMR and mass analyses. In the cytotoxic assays, compounds 1-3 and 7-10 showed inhibition effect against HepG2, MDA-MB-231, and A549 cells with IC50 values ranging from 0.004 to 19.9 μg/mL. Moreover, the anti-inflammatory assays revealed that (-)-matairesinol (8) had significant inhibitory activities on superoxide anion generation (IC50 = 2.7 ± 0.3 μM) and elastase release (IC50 = 6.6 ± 0.7 μM).
PMID: 32223924 [PubMed - as supplied by publisher]

Source: Bioorganic and Medicinal Chemistry Letters - March 19, 2020 Category: Chemistry Authors: Al-Sayed E, Ke TY, Hwang TL, Chen SR, Korinek M, Chen SL, Cheng YB Tags: Bioorg Med Chem Lett Source Type: research