Acid-responsive dextran-based therapeutic nanoplatforms for photodynamic-chemotherapy against multidrug resistance.

Acid-responsive dextran-based therapeutic nanoplatforms for photodynamic-chemotherapy against multidrug resistance. Int J Biol Macromol. 2020 Mar 26;: Authors: Liu L, Bao Y, Zhang Y, Xiao C, Chen L Abstract Limited by multidrug resistance (MDR) and nonspecific selectivity, free molecular chemotherapies still are inefficient in clinical cancer treatment. Nanoscale therapeutics delivery systems with controllable release capacity have been developed to reverse multidrug resistance and improve anticancer efficacy. Herein, we constructed acid-sensitive dextrin-based nanoplatforms (THDP) to deliver chemotherapies via supramolecular coordination between tetra sodium meso-tetra (sulfonatophenyl)-porphyrin zinc (II) (Zn-TPPS) and histidine modified dextrin-graft-poly (ethylene glycol) (HDP) to reverse multidrug resistance through photodynamic-chemotherapy. The introductions of hydrophilic poly (ethylene glycol) (PEG) not only prevent undesired aggregation under physiological conditions but also enhanced cellular endocytosis effect. Doxorubicin loaded nanoplatforms (THDP@DOX) with a relatively uniform size of average 63 nm exhibited excellent stability in blood circulation. When THDP@DOX was internalized, the acidic intercellular environment could control the chemotherapies release. Moreover, the generated reactive oxygen species by photosensitizer Zn-TPPS with light irradiation could obviously block DOX efflux and ultimately induce apoptosi...
Source: International Journal of Biological Macromolecules - Category: Biochemistry Authors: Tags: Int J Biol Macromol Source Type: research