[Research Articles] PBX1 expression in uterine natural killer cells drives fetal growth

We describe a CD49a+PBX homeobox 1 (PBX1)+ dNK cell subset that promotes fetal development in humans and mice. The expression of PBX1 in dNK cells is up-regulated via the activated AKT1 pathway through the interaction of major histocompatibility complex G with the immunoglobulin-like transcript 2 receptor. PBX1 drives pleiotrophin and osteoglycin transcription in dNK cells, further promoting fetal development. Decreased PBX1 expression or the PBX1G21S mutant correlated with fetal growth restriction and pregnancy failure in patients with unexplained recurrent spontaneous abortion (URSA). Inactivation of Pbx1 in mouse dNK cells impairs fetal development by decreasing growth-promoting factors from CD49a+PBX1+ dNK cells. Impairment of PBX1 in dNK cells has positive correlation with URSA pathogenesis and may provide a potential marker for this condition.

Source: Science Translational Medicine - March 31, 2020 Category: Biomedical Science Authors: Zhou, Y., Fu, B., Xu, X., Zhang, J., Tong, X., Wang, Y., Dong, Z., Zhang, X., Shen, N., Zhai, Y., Kong, X., Sun, R., Tian, Z., Wei, H. Tags: Research Articles Source Type: research