Bilateral fibular head prominence: A case report of bilateral chronic knee pain

Publication date: Available online 10 March 2020Source: Current Medicine Research and PracticeAuthor(s): Deepak Kumar Singhal, Brajesh Nandan, Siddharth Agrawal
Source: Current Medicine Research and Practice - Category: General Medicine Source Type: research

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This study is a meta-analysis — a study which includes many studies that are deemed similar enough to lump together, in order to increase the numerical power of the study and, ideally, the strength of the conclusions. The authors included studies that go all the way back to the mid-1990s — a time when cannabis was illegal in the US, different in potency, and when there was no choice or control over strains or cannabinoid compositions, as there is now. One of the studies in the meta-analysis included “cannabis dependent inpatients” in a German psychiatric hospital in which 118 patients were being det...
Source: Harvard Health Blog - Category: Consumer Health News Authors: Tags: Addiction Marijuana Mental Health Source Type: blogs
[Abstract unavailable] Language: en...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Alcohol and Other Drugs Source Type: news
Contributors : Laura S Stone ; Lucas Topham ; Moshe SzyfSeries Type : Methylation profiling by high throughput sequencingOrganism : Mus musculusWe performed genome-wide bisulfite capture sequencing in prefrontal cortex in male mice at four timepoints (one day, two weeks, six months, and one year) post-neuropathic injury in order to track and observe dynamics of DNA methylation and epigenetic regulation in response to the development of chronic pain. We identified hundreds of differentially methylated CpGs and genes at FDR 5%. PFC DNA methylation rapidly and robustly responds to neuropathic injury and genes display time poi...
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Methylation profiling by high throughput sequencing Mus musculus Source Type: research
This JAMA Patient Page describes the risks and possible side effects of taking opioids to treat chronic pain.
Source: JAMA Internal Medicine - Category: Internal Medicine Source Type: research
Following head and neck trauma, the involvement of the cranio-cervical junction (CCJ) and its contribution to a patients transition to chronic pain, is poorly understood. The detection of hypermobility in this...
Source: Chiropractic and Osteopathy - Category: Complementary Medicine Authors: Tags: Research Source Type: research
BACKGROUND: Changes in body representations (body image and/or body schema) have been reported in several chronic musculoskeletal pain syndromes, but rarely in patients with neuropathic pain and never in patients with spinal cord injury (SCI)-related pain....
Source: SafetyLit - Category: International Medicine & Public Health Tags: Economics of Injury and Safety, PTSD, Injury Outcomes Source Type: news
a Patrizia Romualdi Sándor Benyhe Júlia Timár Helmut Schmidhammer Mariana Spetea Mahmoud Al-Khrasani There is growing evidence on the role of peripheral µ-opioid receptors (MORs) in analgesia and analgesic tolerance. Opioid analgesics are the mainstay in the management of moderate to severe pain, and their efficacy in the alleviation of pain is well recognized. Unfortunately, chronic treatment with opioid analgesics induces central analgesic tolerance, thus limiting their clinical usefulness. Numerous molecular mechanisms, including receptor desensitization, G-protein decoupli...
Source: Molecules - Category: Chemistry Authors: Tags: Review Source Type: research
Spinocerebellar ataxia type 10 (SCA10), one of the autosomal dominant ataxias, is characterized by slowly progressive gait ataxia, dysarthria, nystagmus, epilepsy as well as non-motor symptoms [1]. The latter include dysautonomia, cognitive deficits, chronic pain, psychiatric comorbidities and sleep disorders [ [1,2]]. SCA10 is caused by expansion of ATTCT pentanucleotide repeats in the ATXN10 gene – which codes for ataxin 10 [ [1–3]]. Recent experimental data suggested a possible relationship between SCA10 and development of cancer [4].
Source: Parkinsonism and Related Disorders - Category: Neurology Authors: Tags: Correspondence Source Type: research
ConclusionAlthough the clinical benefit of omalizumab in asthma and chronic spontaneous urticaria (CSU) has been established in several clinical trials, there are very little data about its effect on severe VKC. In addition to few previously reported cases we can report the rapid effectiveness of omalizumab in VKC clinically and in terms of quality of life. Randomized trials are needed to include omalizumab in third-line treatment of VKC for prevention of visual impairment and further sequelae such as corneal damage.
Source: Allergo Journal International - Category: Allergy & Immunology Source Type: research
ConclusionsThe qualitative and quantitative measurements used in this study demonstrated good to excellent inter-examiner reliability. Correlation with clinical findings is necessary to establish the utility of these measurements in clinical practice.
Source: Chiropractic and Manual Therapies - Category: Complementary Medicine Source Type: research
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