Nicardipine Inhibits Priming of the NLRP3 Inflammasome via Suppressing LPS-Induced TLR4 Expression

In conclusion, nicardipine exerted anti-inflammatory effects through inhibiting NLRP3 inflammasome pathway. Nicardipine may mitigate NLRP3 primingvia inhibiting NF-kappaB activation, mediated by suppressing LPS-induced TLR4 expression.

http://link.springer.com/10.1007/s10753-020-01215-y

Source: Inflammation - March 31, 2020 Category: Allergy & Immunology Source Type: research

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