The predictors of outcome and progression of pediatric sepsis and septic shock: A prospective observational study from western India

Conclusions: SIRS can progress to septic shock if not identified early. The predictors of mortality were positive blood cultures, multiorgan dysfunction, late hospital admissions, severe acute malnutrition, and requirement of supportive care. The predictors of progression to septic shock were abnormal leukocyte count, culture positivity, and severe acute malnutrition.
Source: Journal of Postgraduate Medicine - Category: Internal Medicine Authors: Source Type: research

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CONCLUSIONS: In our patient, COVID-19 related coagulopathy was associated with poor prognosis. PMID: 32495913 [PubMed - in process]
Source: European Review for Medical and Pharmacological Sciences - Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research
Conclusion: This case suggests that EALT is highly invasive and its clinical course is very aggressive. Intestinal perforation, intestinal obstruction, or involvement of extraintestinal organs may occur in EALT patients. Additionally, EALT patients respond poorly to chemotherapy and have an extremely unfavorable prognosis.
Source: Medicine - Category: Internal Medicine Tags: Research Article: Clinical Case Report Source Type: research
Conclusion(s): Empirical therapy with the high-dose meropenem presented comparable clinical outcomes to the standard-dose meropenem in sepsis and septic shock patients. Besides, subgroup analysis manifested superior microbiological cure rate in sepsis or septic shock patients admitted from ED.
Source: Current Awareness Service for Health (CASH) - Category: Consumer Health News Source Type: news
Conclusion(s): Despite the thyroidal origin of PCT, hypothyroidism did not affect the diagnostic performance of serum PCT levels in predicting bacterial sepsis or septic shock.
Source: Current Awareness Service for Health (CASH) - Category: Consumer Health News Source Type: news
In Reply We agree with Dr Long and colleagues that the timing of interventions is important in the management of sepsis. They suggest that early administration of vitamin C is essential for the intervention to have beneficial effects, even though no data on the timing of intervention were reported in the study by Marik et al. In the VITAMINS trial, an elevated lactate level was required to meet the consensus definition of septic shock. During the study period, sepsis resuscitation in Australasian emergency departments for patients with suspected septic shock was administration of 27 mL/kg of intravenous fluids before start...
Source: JAMA - Category: General Medicine Source Type: research
To the Editor The Vitamin C, Hydrocortisone, and Thiamine in Patients With Septic Shock (VITAMINS) trial found that vitamin C, hydrocortisone, and thiamine, compared with hydrocortisone alone, did not improve outcomes in patients with septic shock.
Source: JAMA - Category: General Medicine Source Type: research
ConclusionVasopressin allowed a reduction of norepinephrine with subsequent LVOTO reduction and hemodynamic improvement of the most severe form of LVOTO, which represented 1.9% of all septic shock patients.
Source: Cardiovascular Drugs and Therapy - Category: Cardiology Source Type: research
Sepsis is a life-threatening organ dysfunction condition caused by a dysregulated host response to an infection. Here we report that the circulating levels of growth and differentiation factor-15 (GDF15) are strongly increased in septic shock patients and correlate with mortality. In mice, we find that peptidoglycan is a potent ligand...
Source: Proceedings of the National Academy of Sciences - Category: Science Authors: Tags: Biological Sciences Source Type: research
Sanjay Zodpey, Himanshu Negandhi, Aman Dua, Akshaya Vasudevan, Mitali RajaIndian Journal of Community Medicine 2020 45(2):117-124 A new strain of coronavirus named severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has overwhelmed the world with its rapid spread and high number of cases. SARS-CoV-2 causes COVID-19 disease which may present with mild, moderate, or severe illness. In severe cases, pneumonia, acute respiratory distress syndrome, sepsis, and septic shock can occur. Individuals above 60 years and people with preexisting comorbidities are at higher risk for developing serious complications. The incuba...
Source: Indian Journal of Community Medicine - Category: International Medicine & Public Health Authors: Source Type: research
Authors: Pampa-Saico S, Pintado V, Muriel A, Caravaca-Fontan F, Yerovi-León E, Rojo-Sanchis A, Del Rey JM, Tenorio MT, Liaño F Abstract BACKGROUND: Colistimethate sodium (CMS) treatment has increased over the last years, being acute kidney injury (AKI) its main drug-related adverse event. Therefore, this study aimed to evaluate the incidence and risk factors associated with AKI, as well as identifying the factors that determine renal function (RF) outcomes at six months after discharge. MATERIALS AND METHODS: This retrospective study included adult septic patients receiving intravenous CMS for at ...
Source: Nefrologia : publicacion oficial de la Sociedad Espanola Nefrologia - Category: Urology & Nephrology Tags: Nefrologia Source Type: research
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