Exocrine Pancreatic Insufficiency in Type 1 and Type 2 Diabetes

This article aims for summarizing current clinical knowledge on screening, diagnosis, and treatment and gives an overview on the pathophysiology of exocrine pancreatic insufficiency in diabetes.Recent FindingsRecent studies reveal novel insights into the close interaction of acinar, ductal, and endocrine cells and the gut-pancreas axis.SummaryExocrine pancreatic insufficiency is a clinically relevant, frequent but poorly understood disorder in both type 1 and type 2 diabetes.
Source: Current Diabetes Reports - Category: Endocrinology Source Type: research

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Diabetic‑induced alterations in hepatic glucose and lipid metabolism: The role of type 1 and type 2 diabetes mellitus (Review). Mol Med Rep. 2020 May 22;: Authors: Jiang S, Young JL, Wang K, Qian Y, Cai L Abstract Diabetes mellitus (DM) is a growing health concern in society. Type 1 and type 2 DM are the two main types of diabetes; both types are chronic diseases that affect glucose metabolism in the body and the impaired regulation of glucose and lipid metabolism promotes the development and progression of DM. During the physiological metabolism process, the liver serves a unique role in glucose and...
Source: Molecular Medicine Reports - Category: Molecular Biology Tags: Mol Med Rep Source Type: research
I have results from my clinic… Three of my diabetic patients went into remission after using hyperbaric oxygen therapy (HBOT). Two patients had type 1 diabetes… and another had type 2 diabetes. All three recovered with oxygen therapy. Most mainstream doctors would scoff at the idea… they “know” there’s no cure for diabetes. And to be treated for it with oxygen seems laughable. If you’re a regular reader, you know more about oxygen therapy than 99% of the general public, including most doctors. But the reason diabetes responds so well to oxygen may surprise you… It al...
Source: Al Sears, MD Natural Remedies - Category: Complementary Medicine Authors: Tags: Health Source Type: news
Publication date: June 2020Source: Canadian Journal of Diabetes, Volume 44, Issue 4Author(s): Kelly Buxton, Lisa M. Lix, Anne Champagne, Charity Evans, Yvonne Shevchuk, Gary Teare, Kerry Mansell, David F. Blackburn
Source: Canadian Journal of Diabetes - Category: Endocrinology Source Type: research
ConclusionOur study indicates a direct link between systemic inflammation and the timely progression of type 1 DM. In patients with type 2 DM, no statistical significance was found between the levels of studied biomarkers and the occurrence of microvascular complications. Nephropathy appeared sooner in type 1 DM patients, while retinopathy and neuropathy had a similar pattern of occurrence in both types of patients.
Source: International Journal of Diabetes in Developing Countries - Category: Endocrinology Source Type: research
J Neurol Surg A Cent Eur Neurosurg DOI: 10.1055/s-0040-1701619 Study Aims Electromyographic (EMG) recordings of the fibularis longus and tibialis anterior muscles were performed intraoperatively during nerve decompression (ND) of the common fibular nerve (CFN) in patients with symptomatic diabetic sensorimotor peripheral neuropathy. Patient demographics and clinical attributes were compared against changes in EMG after ND and analyzed for possible correlations. Methods Intraoperative changes in CFN EMG were analyzed for correlations against sex, age, body mass index (BMI), hemoglobin A1c (A1c), and type and...
Source: Journal of Neurological Surgery Part A: Central European Neurosurgery - Category: Neurosurgery Authors: Tags: Original Article Source Type: research
CONCLUSIONS: There is inconclusive evidence of very low certainty regarding the effects of NNS consumption compared with either sugar, placebo, or nutritive low-calorie sweetener consumption on clinically relevant benefit or harm for HbA1c, body weight, and adverse events in people with type 1 or type 2 diabetes. Data on health-related quality of life, diabetes complications, all-cause mortality, and socioeconomic effects are lacking. PMID: 32449201 [PubMed - in process]
Source: Cochrane Database of Systematic Reviews - Category: General Medicine Authors: Tags: Cochrane Database Syst Rev Source Type: research
Exposure to chronic hyperglycemia because of diabetes mellitus can lead to development and progression of diabetic kidney disease (DKD). We recently reported that reduced superoxide production is associated with mitochondrial dysfunction in the kidneys of mouse models of type 1 DKD. We also demonstrated that humans with DKD have significantly reduced levels of mitochondrion-derived metabolites in their urine. Here we examined renal superoxide production in a type 2 diabetes animal model, the db/db mouse, and the role of a mitochondrial protectant, MTP-131 (also called elamipretide, SS-31, or Bendavia) in restoring renal su...
Source: Journal of Biological Chemistry - Category: Chemistry Authors: Tags: Metabolism Source Type: research
Population cohort study (263,830&2,864,670 people with type 1&2 diabetes respectively) found crude mortality rates for COVID-19 in people with diabetes of 138.3 and 260.6 per 100,000 persons for type 1&2 respectively, with general population rate being 38.8/100,000.
Source: Current Awareness Service for Health (CASH) - Category: Consumer Health News Source Type: news
Authors: Hernández M, Mauricio D Abstract Latent autoimmune diabetes in adults (LADA) is still a poorly characterized entity. However, its prevalence may be higher than that of classical type 1 diabetes. Patients with LADA are often misclassified as type 2 diabetes. The underlying autoimmune process against β-cell has important consequences for the prognosis, comorbidities, treatment choices and even patient-reported outcomes with this diabetes subtype. However, there is still an important gap of knowledge in many areas of clinical relevance. We are herein focusing on the state of knowledge of relevant ...
Source: Advances in Experimental Medicine and Biology - Category: Research Tags: Adv Exp Med Biol Source Type: research
The risk of death from COVID-19 is three and a half times higher for patients with type 1 diabetes and two times higher for those with type 2 diabetes, compared with people without the condition, new NHS research shows.
Source: GP Online News - Category: Primary Care Tags: Coronavirus Source Type: news
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