Complications of Phosphate and Vitamin D Treatment in X-Linked Hypophosphataemia

AbstractConventional treatment of X-linked hypophosphataemia (XLH) consists in the oral administration of phosphate plus calcitriol supplements. Although this therapy has reduced bone deformities and even achieved adequate patient growth, overtreatment or low adherence could lead to subsequent consequences that may compromise the efficacy of the therapy. Some of the complications associated with phosphate and vitamin  D treatment are abdominal discomfort, diarrhoea, hypokalaemia, hyperparathyroidism, hypercalcaemia or hypercalciuria, nephrocalcinosis or nephrolithiasis, and ectopic calcifications. Therefore, constant multidisciplinary monitoring of patients with XLH is necessary to prevent the manifestation of these complications and to deal with them as soon as they appear. The main objective of this article is to review the main complications arising from conventional treatment of XLH and how to deal with them.
Source: Advances in Therapy - Category: Drugs & Pharmacology Source Type: research

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Publication date: Available online 24 May 2020Source: PharmaNutritionAuthor(s): Seyed Mostafa Arabi, Leila Sadat Bahrami, Golnaz Ranjbar, Hamed Tabesh, Abdolreza Norouzy
Source: PharmaNutrition - Category: Nutrition Source Type: research
Publication date: August 2020Source: Biomedicine &Pharmacotherapy, Volume 128Author(s): Xiaokun Han, Xi Chen, Shuilian Chen, Qian Luo, Xuan Liu, Anqi He, Shengyu He, Jin Qiu, Pei Chen, Yihui Wu, Jiejie Zhuang, Meng Yang, Chuangran Wu, Nandan Wu, Ying Yang, Jian Ge, Jing Zhuang, Keming Yu
Source: Biomedicine and Pharmacotherapy - Category: Drugs & Pharmacology Source Type: research
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Source: Wheat Belly Blog - Category: Cardiology Authors: Tags: Open undoctored vitamin D wheat belly Source Type: blogs
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Source: Advances in Experimental Medicine and Biology - Category: Research Tags: Adv Exp Med Biol Source Type: research
Conditions:   Vitamin D Status;   Osteoporosis;   Sarcopenia Intervention:   Sponsors:   University of Ulster;   Western Health and Social Care Trust Suspended
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
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Source: Chemosphere - Category: Chemistry Authors: Tags: Chemosphere Source Type: research
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Source: Environmental Pollution - Category: Environmental Health Authors: Tags: Environ Pollut Source Type: research
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Source: PediatricEducation.org - Category: Pediatrics Authors: Tags: Uncategorized Source Type: news
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Source: Food Research International - Category: Food Science Source Type: research
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Source: The Economic Times Healthcare and Biotech News - Category: Pharmaceuticals Source Type: news
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