Effects of Estrogen on Cardiac mRNA and LncRNA Expression Profiles in Hypertensive Mice

This study was to address the possible mechanisms that may explain the relationship between estradiol configuration —17β-estradiol (E2) and ventricular remodeling. Here, we show that a total of 1499 LncRNAs and 680 mRNAs significantly differently expressed were identified. This result indicates that estradiol has a global role in regulating heart gene expression profiles in female mice. Go and Pathway function al cluster analysis showed that the antagonism of E2 on cardiac remodeling and AngII-induced pathological changes in female mice may be related to physiological processes such as circadian rhythm disorder and ion channel dysfunction.Graphical Abstract
Source: Journal of Cardiovascular Translational Research - Category: Cardiology Source Type: research