GSE54003 Expression data from mouse with vasectomy or sham surgery

Contributors : Hiroshi Ishiguro ; Takashi KawaharaSeries Type : Expression profiling by arrayOrganism : Mus musculusVasectomy was thought to be a risk factor for prostate cancer. We investigated the mechanism on vasectomy using Affymetrix microarray.
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by array Mus musculus Source Type: research

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ConclusionWe found a small statistically significant increase in PCa incidence after vasectomy, but in contrast the mortality of vasectomized men was significantly reduced. This may be due to higher likelihood of vasectomized men to undergo prostate-specific antigen testing, having healthier general lifestyle and other biological factors e.g. high reproductive fitness.
Source: Cancer Epidemiology - Category: Cancer & Oncology Source Type: research
Abstract Vasitis or inflammation of the vas deferens is a rarely described condition categorized as either generally asymptomatic vasitis nodosa or the acutely painful infectious vasitis. Vasitis nodosa, the commonly described inflammation of the vas deferens, is benign and usually associated with a history of vasectomy. Clinically, patients present with a nodular mass and are often asymptomatic and require no specific treatment.
Source: International Braz J Urol - Category: Urology & Nephrology Source Type: research
Abstract Vasitis or inflammation of the vas deferens is a rarely described condition categorized as either generally asymptomatic vasitis nodosa or the acutely painful infectious vasitis. Vasitis nodosa, the commonly described inflammation of the vas deferens, is benign and usually associated with a history of vasectomy. Clinically, patients present with a nodular mass and are often asymptomatic and require no specific treatment.
Source: International Braz J Urol - Category: Urology & Nephrology Source Type: research
A new study suggests that vasectomy increases the risk for prostate cancer over a long-term follow-up, although that risk is small compared with nonvasectomized men.Medscape Medical News
Source: Medscape Hematology-Oncology Headlines - Category: Cancer & Oncology Tags: Hematology-Oncology News Source Type: news
Conclusions were similar when using pro pensity adjustment and matching. Importantly, a significant interaction between vasectomy and PSA screening was identified.DiscussionEstimates of the association between vasectomy and prostate cancer are sensitive to analytic method underscoring the tenuous nature of the connection. Given the differences between men who do and do not utilize vasectomy, selection bias appears likely to explain any identified association between vasectomy and prostate cancer.ConclusionsWith over 20  years of follow‐up, no convincing relationship between vasectomy and prostate cancer of any grade was identified.
Source: Andrology - Category: Urology & Nephrology Authors: Tags: Original Article Source Type: research
B. Bhindi, C. J. D. Wallis, M. Nayan, A. M. Farrell, L. W. Trost, R. J. Hamilton, G. S. Kulkarni, A. Finelli, N. E. Fleshner, S. A. Boorjian and R. J. Karnes
Source: The Journal of Urology - Category: Urology & Nephrology Authors: Tags: Urological Survey Source Type: research
Whether vasectomy causes prostate cancer has been debated for 30 years. To date studies have primarily compared the prostate cancer incidence between men who underwent vasectomy and various control groups (reference 12 in article). Randall et al approached this topic differently, examining whether vasectomy reversal is associated with a reduced prostate cancer risk among men who have undergone vasectomy. According to the criteria of causality of Hill, if vasectomy truly causes prostate cancer, vasectomy reversal should theoretically decrease this risk.
Source: The Journal of Urology - Category: Urology & Nephrology Authors: Tags: Adult Urology Source Type: research
Evidence on the effect of vasectomy on prostate cancer is conflicting, with the issue of detection bias a key criticism. We examine the effect of vasectomy reversal on prostate cancer risk in a cohort of vasectomised men; evidence of a protective effect would be consistent with a harmful effect of vasectomy on prostate cancer risk, while nullifying the issue of detection bias.
Source: The Journal of Urology - Category: Urology & Nephrology Authors: Source Type: research
We examined the effect of vasectomy reversal on prostate cancer risk in a cohort of vasectomized men. Evidence of a protective effect would be consistent with a harmful effect of vasectomy on prostate cancer risk while nullifying the issue of detection bias.
Source: The Journal of Urology - Category: Urology & Nephrology Authors: Tags: Adult Urology Source Type: research
We examined the effect of vasectomy reversal on prostate cancer risk in a cohort of vasectomized men. Evidence of a protective effect would be consistent with a harmful effect of vasectomy on prostate cancer risk while nullifying the issue of detection bias.
Source: The Journal of Urology - Category: Urology & Nephrology Authors: Tags: Adult Urology Source Type: research
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