Surgical Management of Deep Brain Stimulator Infection without Electrode Removal: Report of Two Cases

Conclusion DBS is always associated with a risk of infection or exposure of components and treatment can be very difficult. We successfully managed intractable wound infection while leaving the electrode lead in situ, so that it was subsequently possible to continue DBS for Parkinson's disease. [...] Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Abstract  |  open access Full text
Source: Journal of Neurological Surgery Reports - Category: Neurosurgery Authors: Tags: Case Report Source Type: research

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This study aimed to characterize the neurophysiological correlates of gait in the human pedunculopontine nucleus (PPN) region and the globus pallidus internus (GPi) in Parkinson’s disease (PD) cohort. Though much is known about the PPN region through animal studies, there are limited physiological recordings from ambulatory humans. The PPN has recently garnered interest as a potential deep brain stimulation (DBS) target for improving gait and freezing of gait (FoG) in PD. We used bidirectional neurostimulators to record from the human PPN region and GPi in a small cohort of severely affected PD subjects with FoG desp...
Source: Frontiers in Human Neuroscience - Category: Neuroscience Source Type: research
Condition:   Parkinson Disease Intervention:   Other: Cycling deep brain stimulation Sponsor:   University of Sao Paulo General Hospital Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
V, Petrák V, Taylor A Abstract In this work we report on the implementation of methods for data processing signals from microelectrode arrays (MEA) and the application of these methods for signals originated from two types of MEAs to detect putative neurons and sort them into subpopulations. We recorded electrical signals from firing neurons using titanium nitride (TiN) and boron doped diamond (BDD) MEAs. In previous research, we have shown that these methods have the capacity to detect neurons using commercially-available TiN-MEAs. We have managed to cultivate and record hippocampal neurons for the first ...
Source: Physiological Research - Category: Physiology Authors: Tags: Physiol Res Source Type: research
Authors: Gomez-Inhiesto E, Acaiturri-Ayesta MT, Ustarroz-Aguirre I, Camahuali D, Urtaran-Laresgoiti M, Basabe-Aldecoa M, Nuño-Solinís R, Urizar E Abstract Parkinson's disease is one of the main reasons for neurological consultation in Spain. Due to the nature of the disease, it impacts patients, families, and caregivers. Parkinson's disease is a degenerative disease with no cure, although second-line therapies have recently improved the quality of life of patients in advanced stages. The aim of this study was to analyse the costs of the following therapies: deep brain stimulation (DBS), continuous duo...
Source: Parkinsons Disease - Category: Neurology Tags: Parkinsons Dis Source Type: research
Publication date: June 2020Source: The Lancet Neurology, Volume 19, Issue 6Author(s): Jerrold L Vitek, Roshini Jain, Lilly Chen, Alexander I Tröster, Lauren E Schrock, Paul A House, Monique L Giroux, Adam O Hebb, Sierra M Farris, Donald M Whiting, Timothy A Leichliter, Jill L Ostrem, Marta San Luciano, Nicholas Galifianakis, Leo Verhagen Metman, Sepehr Sani, Jessica A Karl, Mustafa S Siddiqui, Stephen B Tatter, Ihtsham ul Haq
Source: The Lancet Neurology - Category: Neurology Source Type: research
Publication date: June 2020Source: The Lancet Neurology, Volume 19, Issue 6Author(s): Günther Deuschl, Paul Krack
Source: The Lancet Neurology - Category: Neurology Source Type: research
Authors: Negri M, Gorgora M, Nasser JA, Salles JI, Teixeira S, Arias-Carrión O, Junqueira J, Nicoliche E, Velasques B, Cagy M, Budde H, Basile LF, Orsini M, Friede R, Bastos VH, Ribeiro P Abstract Chronic deep brain stimulation (CDBS) is a surgical treatment that reduces the cardinal signs of Parkinson's disease (PD). Although CDBS has been in use for a long time, very little has been reported on its supposed effects on cognition, particularly in relation to implants in the subthalamic nucleus. The results of the rare studies that do exist are controversial, and in many cases the studies have several design ...
Source: Functional Neurology - Category: Neurology Tags: Funct Neurol Source Type: research
Fifty-five (55) cm 8 Contact Extension Kit, part number M365NM3138550 - Product Usage: The Deep Brain Stimulation (DBS) System is indicated for use in bilateral stimulation of the subthalamic nucleus (STN) as an adjunctive therapy in reducing some of the symptoms of moderate to advanced levodopa-responsive Parkinson s disease (PD) that are not adequately controlled with medication.
Source: Medical Device Recalls - Category: Medical Devices Source Type: alerts
Abstract OBJECTIVE: Deep brain stimulation (DBS) is a well-established therapy for treating neurological movement disorders. Some patients who have received DBS therapy have noticed significant weight gain. Further investigation into correlations between patient characteristics and weight gain following DBS device implantation, which the authors here have done, will provide physicians with useful clinical information. METHODS: The authors performed a retrospective study of patients with Parkinson's disease (PD) and essential tremor (ET) who had received DBS therapy in the period from 2012 to 2017. Patient wei...
Source: Journal of Neurosurgery - Category: Neurosurgery Authors: Tags: J Neurosurg Source Type: research
Efforts of subthalamic nucleus deep brain stimulation on cognitive spectrum: From explicit to implicit changes in the patients with Parkinson's disease for 1 year. CNS Neurosci Ther. 2020 May 21;: Authors: You Z, Wu YY, Wu R, Xu ZX, Wu X, Wang XP Abstract OBJECTIVE: To evaluate the cognitive function of Chinese patients with Parkinson's disease PD postsubthalamic nucleus deep brain stimulation (STN-DBS). METHODS: Cognitive function was assessed by neuropsychological methods in PD patients. Twenty matched healthy persons served as normal controls. t test, analysis of variance, and chi-square ...
Source: CNS Neuroscience and Therapeutics - Category: Neuroscience Authors: Tags: CNS Neurosci Ther Source Type: research
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