Studying the Correlation between Neutrophils and miR21 Expression: Role in Bronchiolitis Obliterans Syndrome
Bronchiolitis obliterans syndrome (BOS) is associated with poor long-term survival. In its pathogenesis neutrophils (NEU) are recognized as relevant players. Moreover, our group has recently showed that some microRNAs (miRs) may act as pro-fibrotic effectors in the context of BOS highlighting the role of miR21, whose expression was higher in BOS lungs respective to healthy lungs. Our aim was to assess whether activated NEU might contribute to epithelial mesenchymal transition (EMT) through the up regulation of miR21 in lung cells.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: L. Pandolfi, S. Bozzini, V. Frangipane, M. D'Amato, M. Morosini, E. Rossi, F. Meloni Tags: (1205) Source Type: research
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