Single Cell Profiling Identifies Novel B Cell Populations That Drive Chronic Rejection after Lung Transplantation

Despite immunosuppressive T cell-targeting therapies, the survival rate after LTx remains as low as 50% after 5 years, mainly due to the development of BOS. The T cell centric paradigm is being increasingly challenged in solid organ transplantation. We recently demonstrated in a new mouse model of lymphocytic bronchiolitis (LB) after orthotopic LTx that B cells played a central role in the development of BOS. Alarming experiences from the past strongly suggest that a systemic B cell depletion must be considered with caution if at all.

Source: The Journal of Heart and Lung Transplantation - March 31, 2020 Category: Transplant Surgery Authors: N. Smirnova, K. Riemondy, S. Collins, J. Hesselberth, O. Eickelberg Tags: (1213) Source Type: research