Circulating Exosomes from Human Lung Transplant Recipients with Rejection Induces IL-6 by Rab27A Signaling and Promotes Epithelial Mesenchymal Transition of Airway Epithelial Cells In Vitro

Exosomes are small membrane vesicles that regulate intracellular function and cell-to-cell communication. Our report has shown circulating exosomes are induced during lung allograft rejection (Am J Transplant, 2017; 17:474-484). Rab27, a member of the Rab subfamily of GTPases, is essential for exosome secretion. The aim of this study is to determine the role of Rab27A signaling in human bronchial epithelial cells (BEAS-2B) stimulated with exosomes from human lung transplant recipients (LTxRs) diagnosed with acute rejection, bronchiolitis obliterans syndrome (BOS), or stable.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Tags: (1218) Source Type: research