Tricuspid Surgery and Pulmonary Thromboendarterectomy in Patients with Chronic Thromboembolic Pulmonary Hypertension

Pulmonary Thormboendarterectomy (PTE) has been shown to reduce tricuspid regurgitation. Tricuspid valve repair or replacement (TVR) in addition to the PTE has been used primarily in patients with more severe tricuspid regurgitation (TR), but the effects have not been evaluated.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Tags: (1307) Source Type: research

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Authors: Gocho K, Kimura T, Hamanaka N, Ishii T, Takemura T, Shimizu K Abstract In the 2013 updated classification of the American Thoracic Society/European Respiratory Society, airway-centered interstitial fibrosis (ACIF) is included as a bronchiolocentric pattern of interstitial pneumonia (IP) among idiopathic IPs. We encountered a case of severe pulmonary hypertension (PH) with chronic IP. The patient initially presented with shortness of breath and often lost consciousness due to PH, and seven years after his first visit, he ultimately died. An autopsy revealed ACIF and usual IP. In particular, the ACIF compri...
Source: Internal Medicine - Category: Internal Medicine Tags: Intern Med Source Type: research
ConclusionsFrom the results of the CEPH model dogs, autonomic dysfunction was shown to occur in PH dogs. In addition, the administration of 1  mg/kg of sildenafil to CEPH model dogs may improve autonomic dysfunction.
Source: Veterinary Research Communications - Category: Veterinary Research Source Type: research
In patients with significant tricuspid regurgitation (TR) the conventional markers for the assessment of right ventricular (RV) systolic function may be less accurate. Tricuspid annular plane systolic excursion (TAPSE) indexed to systolic pulmonary artery pressure (SPAP) (TAPSE/SPAP) may be prognostically useful in pulmonary hypertension and left ventricular dysfunction. Our aim was to explore its use in patients with moderate or severe TR.
Source: International Journal of Cardiology - Category: Cardiology Authors: Source Type: research
Over the last several decades, we have witnessed a dramatic shift in the congenital heart disease population from mostly children to now adults by a two-thirds margin. The diverse anatomies and physiologies, surgical procedures, and adult co-morbidities, has created the most unique population in cardiovascular medicine - adults with congenital heart disease (ACHD). Patients with ACHD may develop complex arrhythmias, valvular heart disease, heart failure, pulmonary hypertension and require complex advanced imaging, electrophysiologic, transcatheter, and/or surgical interventions to improve their quality of life.
Source: Cardiology Clinics - Category: Cardiology Authors: Tags: Preface Source Type: research
Conclusions: Endogenous blood-borne transport of miR-210 into pulmonary vascular endothelial cells promotes PH, offering fundamental insight into the systemic physiology of miRNA activity. These results also describe a platform for RNA-mediated crosstalk in PH, providing an impetus for developing blood-based miR-210 technologies for diagnosis and therapy in this disease. PMID: 32493166 [PubMed - as supplied by publisher]
Source: Circulation Research - Category: Cardiology Authors: Tags: Circ Res Source Type: research
There are limited published data defining survival and treatment response in patients with mild lung disease and/or reduced gas transfer who fulfil diagnostic criteria for idiopathic pulmonary arterial hypertension (IPAH). Patients diagnosed with IPAH between 2001 and 2019 were identified in the ASPIRE (Assessing the Spectrum of Pulmonary Hypertension Identified at a Referral Centre) registry. Using prespecified criteria based on computed tomography (CT) imaging and spirometry, patients with a diagnosis of IPAH and no lung disease were termed IPAHno-LD (n=303), and those with minor/mild emphysema or fibrosis were described...
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Pulmonary vascular disease Original Articles: Pulmonary hypertension Source Type: research
Pulmonary hypertension (PH) in the context of chronic lung disease (i.e. group 3 PH) is an ongoing and unresolved challenge. Looking specifically into precapillary PH, it is evident that its presence in chronic lung disease is associated with increased dyspnoea, reduced exercise tolerance, worsened oxygenation, low diffusion capacity of the lung for carbon monoxide (DLCO) and dismal prognosis. Noteably, pulmonary vascular disease is known to negatively impact clinical outcomes in chronic lung disease, even though the definition of precapillary PH may not yet be fulfilled [1]. Vice versa, the presence of mild or subclinical...
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Editorials Source Type: research
Publication date: August 2020Source: IJC Heart &Vasculature, Volume 29Author(s): M.C.J. van Thor, R.J. Snijder, J.C. Kelder, J.J. Mager, M.C. Post
Source: IJC Heart and Vasculature - Category: Cardiology Source Type: research
Obesity and pulmonary hypertension (PH) share common characteristics, such as augmented inflammation and oxidative stress. However, the exact role of obesity in the pathology of PH is largely uninvestigated. T...
Source: Respiratory Research - Category: Respiratory Medicine Authors: Tags: Research Source Type: research
CONCLUSIONS: Treprostinil can improve the early postoperative prognosis of patients with severe left heart valvular disease combined with severe PAH undergoing prosthetic valve replacement. PMID: 32493870 [PubMed - as supplied by publisher]
Source: Annals of Thoracic and Cardiovascular Surgery - Category: Cardiovascular & Thoracic Surgery Authors: Tags: Ann Thorac Cardiovasc Surg Source Type: research
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