Intestinal Microbiome Composition Changes after Heart Transplant

Alterations to the intestinal microbiome prior to bone marrow transplant (BMT) are associated with post-BMT mortality, and distinct compositional changes (increase in Firmicutes and decrease in Bacteroidetes) are present in adults with cardiovascular (CV) disease. We hypothesize that alterations to the intestinal microbiome occur in children after pediatric heart transplant (HTx).
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Tags: (1161) Source Type: research

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We have previously reported that transient mixed hematopoietic chimerism induced via donor bone marrow transplantation can achieve tolerance to cardiac allografts in non-human primates (NHPs). The purpose of this study was to measure the frequency and properties of a unique subset of CD8+ B cells, recently identified in our laboratory, in tolerant monkeys.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Tags: (195) Source Type: research
Induction of tolerance in combined heart/kidney transplantation in non-human primates is possible by applying a mixed chimerism-based conditioning protocol which induces indefinite tolerance. However, donor brain death negatively impacts tolerance induction, leading to a higher incidence of humoral as well as cellular rejection. Here, we investigated whether delaying conditioning and donor bone marrow transplantation (DBMT) until four months after organ transplantation would diminish the detrimental effects of donor brain death and permit tolerance induction despite donor brain death.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Tags: (1214) Source Type: research
The United States Public Health Service Flag Promotion ceremony for Rear Admiral (RADM) Richard W. Childs, promoted to RADM Upper Half O-8 in January 2020, is being webcast live on 3/27/2020 from Masur Auditorium. Richard Childs, MD serves as the Clinical Director of the National Heart, Lung, and Blood Institute (NHLBI) at the National Institutes of Health (NIH). He was commissioned in the USPHS Commissioned Corps as a Lieutenant in 1995 when joined the NCI as an Oncology Fellow. Following fellowship training, he was appointed a tenure-track investigator in the Hematology Branch of the NHLBI where he continues to conduct r...
Source: Videocast - All Events - Category: General Medicine Tags: Upcoming Events Source Type: video
In conclusion, taller body height at the entry to adulthood, supposed to be a marker of early-life environment, is associated with lower risk of dementia diagnosis later in life. The association persisted when adjusted for educational level and intelligence test scores in young adulthood, suggesting that height is not just acting as an indicator of cognitive reserve. A Comparison of Biological Age Measurement Approaches https://www.fightaging.org/archives/2020/02/a-comparison-of-biological-age-measurement-approaches/ Researchers here assess the performance of a range of approaches to measuring biological...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
UCLA researchers are part of an international team that reported the use of a stem cell gene therapy to treat nine people with the rare, inherited blood disease known as X-linked chronic granulomatous disease, or X-CGD. Six of those patients are now in remission and have stopped other treatments. Before now, people with X-CGD – which causes recurrent infections, prolonged hospitalizations for treatment, and a shortened lifespan – had to rely on bone marrow donations for a chance at remission.“With this gene therapy, you can use a patient’s own stem cells instead of donor cells for a transplant,&rdqu...
Source: UCLA Newsroom: Health Sciences - Category: Universities & Medical Training Source Type: news
In this study, we investigated the link between AF and senescence markers through the assessment of protein expression in the tissue lysates of human appendages from patients in AF, including paroxysmal (PAF) or permanent AF (PmAF), and in sinus rhythm (SR). The major findings of the study indicated that the progression of AF is strongly related to the human atrial senescence burden as determined by p53 and p16 expression. The stepwise increase of senescence (p53, p16), prothrombotic (TF), and proremodeling (MMP-9) markers observed in the right atrial appendages of patients in SR, PAF, and PmAF points toward multiple inter...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
Esteban Jaramillo, 38, received a double lung transplant at Ronald Reagan UCLA Medical Center this past August after both of his lungs collapsed. He had faced health challenges in the past, having undergone a bone marrow transplant 14 years ago, but he didn ’t expect to develop a lung condition as well. Despite these hardships, Jaramillo remained hopeful.“Since I was a kid my grandma told me to have a lot of faith,” he said. “UCLA is a place where miracles of science really happen. I got my life back here.”Jaramillo ’s success story is one of many that were celebrated recently at the UCL...
Source: UCLA Newsroom: Health Sciences - Category: Universities & Medical Training Source Type: news
A drug developed by UCLA physician-scientists and chemists speeds up the regeneration of mouse and human blood stem cells after exposure to radiation. If the results can be replicated in humans, the compound could help people recover quicker from chemotherapy, radiation and bone marrow transplants.The study, published in Nature Communications,also sheds light on the basic biology behind blood stem cell regeneration and the role of a specific molecular process that is blocked by the new drug. Blood stem cells reside in the bone marrow and produce all of the body ’s blood and immune cells.“We’re very excite...
Source: UCLA Newsroom: Health Sciences - Category: Universities & Medical Training Source Type: news
Discussion Transplantation is not a common problem for primary care physicians but when a child’s disease has progressed to end-stage organ failure, transplantation can be the only treatment available. While the primary care provider usually is not involved in the daily management of patients before, during and after transplantation, they can be involved in many areas. These can include providing appropriate primary and acute care, ordering and obtaining necessary medical tests, medications and equipment, assisting with medical insurance, providing medical history and records to consultants, translating medical infor...
Source: PediatricEducation.org - Category: Pediatrics Authors: Tags: Uncategorized Source Type: news
Background: 2D strain imaging detects subclinical myocardial dysfunction in a range of disease states; however strain analysis has largely been applied to the left ventricle.
Source: Heart, Lung and Circulation - Category: Cardiology Authors: Tags: 325 Source Type: research
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