Coagulation Monitoring Correlation with Bivalirudin Dosing in Pediatric Ventricular Assist Device Support

The use of bivalirudin has increased dramatically for primary thromboprophylaxis in pediatric paracorporeal ventricular assist device (VAD) support with limited data on optimal monitoring of effect. Partial thromboplastin time (aPTT) is commonly used for monitoring of bivalirudin, but can be impacted by line heparin, variability in assays and other patient factors. As such, we sought to examine the correlation of PTT to International Normalized Ratio (INR), as a possible monitoring tool for bivalirudin in in pediatric VAD patients.

Source: The Journal of Heart and Lung Transplantation - March 31, 2020 Category: Transplant Surgery Authors: C. Knoll, B. Blume, C. Ventresco, B. Hawkins, M. Ghbeis, K.P. Daly, C. VanderPluym Tags: (1191) Source Type: research