Pulmonary Hypertension Resolves Post Transplantation in Patients Treated with Milrinone or Dobutamine

Heart failure (HF) represents a significant cause of morbidity and mortality in the US. Heart transplantation can lead to significant long-term survival. One complication of HF is the presence of pulmonary hypertension (PH) secondary to increased left heart pressures. The presence of fixed PH is a contraindication to heart transplantation. Milrinone is hypothesized to lead to pulmonary vasodilation through its inhibition of PDE-4 and may be the better inotrope in patients with PH being evaluated for transplantation.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Tags: (677) Source Type: research